Du, Mengyuan published the artcileN-Protecting group tuning of the enantioselectivity in Strecker reactions of trifluoromethyl ketimines to synthesize quaternary α-trifluoromethyl amino nitriles by ion pair catalysis, SDS of cas: 5860-95-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(10), 1581-1584, database is CAplus and MEDLINE.
An enantioselective Strecker reaction to construct trifluoromethylated quaternary stereocenters with N-PMP and unexplored N-Boc trifluoromethyl ketimines RC(CF3)=NR1 [R = Ph, 3,5-difluorophenyl, thiophen-2-yl, etc.; R1 = 4-methoxyphenyl, C(O)OC(CH3)3] catalyzed using an organophosphine dual-reagent catalyst has been developed. The enantioselectivities of the corresponding products (R/S)-RC(CF3)(CN)NH(R1) with the same catalyst could be switched by using different N-protecting groups (N-PMP or N-Boc). The trifluoromethyl amino nitriles (R/S)-RC(CF3)(CN)NH(R1) were obtained in high yield and high enantioselectivity in a short time and could be easily converted to a variety of useful trifluoromethyl-containing compounds
Chemical Communications (Cambridge, United Kingdom) published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, SDS of cas: 5860-95-7.
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