Yu, Haihua published the artcileControllable access to multi-substituted imidazoles via palladium(
A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles I [R1 = Me, CF3, Ph, etc.; R2 = H, Ph, Bn; R3 = H, Me; R4 = Ph, 4-FC6H4, 2-MeC6H4, etc.] via cascade palladium catalyzed C-C coupling followed by intramol. C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield. The protocol was the first report to prepare multi-substituted imidazoles from readily accessible aminoacetonitrile and boronic acid.
Chemical Communications (Cambridge, United Kingdom) published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C19H21N3O3S, Formula: C9H12BClO3.
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