Tian, Jun-Jie published the artcileBorane-Catalyzed Chemoselective and Enantioselective Reduction of 2-Vinyl-Substituted Pyridines, Safety of N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Angewandte Chemie, International Edition (2020), 59(42), 18452-18456, database is CAplus and MEDLINE.
Herein, we report that highly chemoselective and enantioselective reduction of 2-vinyl-substituted pyridines has been achieved for the first time. The reaction, which uses chiral spiro-bicyclic bisboranes as catalysts and HBpin and an acidic amide as reducing reagents, proceeds through a cascade process involving 1,4-hydroboration followed by transfer hydrogenation of a dihydropyridine intermediate. The retained double bond in the reduction products permits their conversion to natural products and other useful heterocyclic compounds by simple transformations.
Angewandte Chemie, International Edition published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H14O2, Safety of N-Benzyl-N,N-dibutylbutan-1-aminium chloride.
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