Wodtke, Robert published the artcileSynthesis and kinetic characterization of water-soluble fluorogenic acyl donors for transglutaminase 2, Application of 2-Chlorotrityl chloride, the publication is ChemBioChem (2016), 17(13), 1263-1281, database is CAplus and MEDLINE.
Small Glu-containing peptides bearing coumarin derivatives as fluorescent leaving groups attached to the γ-carboxylic acid group of the Glu residue were synthesized and investigated with regard to their potential to act as substrates for transglutaminase 2 (TGase 2). Their synthesis was accomplished by an efficient solid-phase approach. The excellent water solubility of the compounds enabled their extensive kinetic characterization in the context of TGase 2-catalyzed hydrolysis and aminolysis. The influence of the coumarin skeleton’s substitution pattern on the kinetic properties was studied. Derivatives containing 7-hydroxy-4-methylcoumarin (HMC) revealed properties superior to those of their 7-hydroxycoumarin counterparts; analogous amides were not accepted as substrates. Z-Glu(HMC)-Gly-OH, which exhibited the best substrate properties out of the investigated derivatives, was selected for representative kinetic characterization of acyl acceptor substrates and irreversible inhibitors.
ChemBioChem published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H13BrSi, Application of 2-Chlorotrityl chloride.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics