O’Hagan, Michael P. published the artcileVisible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology, Formula: C15H14Cl2S2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(38), 5186-5189, database is CAplus and MEDLINE.
We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiol.-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacol. strategies.
Chemical Communications (Cambridge, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Formula: C15H14Cl2S2.
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