Jellen, Emily E. published the artcileProbing the stability and structure of metalloporphyrin complexes with basic peptides by mass spectrometry, Quality Control of 6249-56-5, the publication is European Journal of Mass Spectrometry (2005), 11(1), 65-72, database is CAplus and MEDLINE.
The stability and structure of noncovalent complexes of various peptides containing basic amino acid residues (Arg, Lys) with metalloporphyrins were studied in a quadrupole ion trap mass spectrometer. The complexes of heme and three other metalloporphyrins with a variety of basic peptides and model systems were formed via electrospray ionization (ESI) and their stability was probed by energy-variable collision-induced dissociation (CID). A linear dependence for basic peptides and model compounds/metalloporphyrin complexes was observed in the plots of stability vs. degrees of freedom and was used to evaluate relative bond strength. These results were then compared with previous data obtained for complexes of metalloporphyrins with His-containing peptides and peptides containing no basic amino acids. The binding strengths of Lys-containing peptide complexes in the gas phase is almost as strong as that of Arg-containing complexes. Both systems showed stronger binding than His-containing peptides studied previously. To probe the structure of Arg and Lys noncovalent complexes (charge solvation vs. salt bridges), two techniques, CID and ion-mol. reactions, were used. CID experiments indicate that the gas-phase complexes are most likely formed by charge solvation of the central metal ion in the metalloporphyrin by basic side chains of Arg or Lys. Results from the ion-mol. reaction studies are consistent with the charge solvation structure as well.
European Journal of Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Quality Control of 6249-56-5.
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