Darroudi, Mahdieh’s team published research in Applied Organometallic Chemistry in 34 | CAS: 3696-23-9

Applied Organometallic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, COA of Formula: C7H7ClN2S.

Darroudi, Mahdieh published the artcileSynthesis of Novel Triazole Incorporated Thiazolone Motifs Having Promising Antityrosinase Activity through Green Nanocatalyst CuI-Fe3O4@SiO2 (TMS-EDTA), COA of Formula: C7H7ClN2S, the publication is Applied Organometallic Chemistry (2020), 34(12), e5962, database is CAplus.

In the present work, novel 5-((1-benzyl-1,2,3-triazol-4-yl)methoxybenzylidene)-2-(arylamino)thiazol-4-one thiazolone incorporated triazole derivatives I and II was designed as tyrosinase inhibitors. The compounds I and II were synthesized through click reaction in good yield. Moreover, the antityrosinas activity of the synthesized derivatives I and II was evaluated. In the search for establishing a click copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction under strict conditions, in terms of a novel air-stable, a recyclable and efficient magnetic catalyst was planned for new triazole derivatives as a well-organized copper iodide supported on the functionalized Fe3O4@SiO2 core-shell (CuI/Fe3O4@SiO2(TMS-EDTA) nanoparticles). The engineered nanocatalyst synthesized for the first time and characterized by different methods, including FT-IR spectroscopy, XRD, FESEM, EDX, TEM, TGA, and BET anal. The excellent catalytic performance in ethanol with high surface area (351.7 m2g-1) and short reaction time for diverse functional groups (120-200 min), no use of toxic solvents, reusability of the catalyst, and using eco-friendly conditions were the advantageous of this work. Moreover,the nanocatalyst was used at least five times without any significant decrease in the yield of the reaction. The thiazolidine-triazole derivatives I [X=Y=Z = H, X=Y = H; Z = Br, X = 4-N; Y = H; Z = 2-Cl and X = 4-N; Y = H; 3,4-di-Cl] showed promising tyrosinase inhibitory activity with IC50 values in the range of 5.90-9.81μM. The compounds I and II were found to be considerably more potent tyrosinase inhibitors than the reference inhibitor kojic acid (IC50 = 18.36μM).

Applied Organometallic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, COA of Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics