Bryant, Laura A. published the artcileEnantioselective Organocatalytic Synthesis of Bicyclic Resorcinols via an Intramolecular Friedel-Crafts-Type 1,4-Addition: Access to Cannabidiol Analogues, Category: chlorides-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2021), 363(16), 4067-4074, database is CAplus and MEDLINE.
A highly enantioselective, organocatalytic intramol. cyclization by a Friedel-Crafts-type 1,4-addition using a Joergensen-Hayashi-like organocatalyst with a large silyl protecting group and showed that heat improved the reaction yield with virtually no detriment to enantioselectivity. A variety of bicyclic resorcinols were obtained with excellent enantioselectivities (up to 94%). To show the utility of these constructs, and as part of a wider project involved the synthesis of cannabinoid-like compounds, the resorcinol formed was used to generate both ‘normal’ and ‘abnormal’ cannabidiol which had anticonvulsant activity.
Advanced Synthesis & Catalysis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Category: chlorides-buliding-blocks.
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