Ahn, Ki Chang published the artcileDetection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay, Category: chlorides-buliding-blocks, the publication is Environmental Science & Technology (2016), 50(7), 3754-3761, database is CAplus and MEDLINE.
A sensitive, competitive ELISA for the detection of the antimicrobial triclosan (TCS) was developed. Novel immunizing haptens were synthesized by derivatizing at the 4-Cl position of the TCS mol. Compounds derived from substitutions at 4′-Cl and that replaced the 2′-OH with a Cl atom were designed as unique coating antigen haptens. Polyclonal rabbit antisera were screened against the coating antigen library to identify combinations of immunoreagents resulting in the most sensitive assays. The most sensitive assay identified was one utilizing antiserum number 1155 and a heterologous competitive hapten, where the 2′-OH group was substituted with a Cl atom. An IC50 value and the detection range for TCS in assay buffer were 1.19 and 0.21-6.71 μg/L, resp. The assay was selective for TCS, providing low cross-reactivity (<5%) to the major metabolites of TCS and to brominated di-Ph ether-47. A 2nd assay using a competitive hapten containing Br instead of Cl substitutions was broadly selective for both brominated and chlorinated diphenylethers. Using the most sensitive assay combination, we measured TCS concentrations in water following dilution Biosolid samples were analyzed following the dilution of a simple solvent extract The immunoassay results were similar to those determined by LC-MS/MS. This immunoassay can be used as a rapid and convenient tool to screen for human and environmental exposure.
Environmental Science & Technology published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Category: chlorides-buliding-blocks.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics