Zeiger, Errol published the artcileThe Proportions of Mutagens among Chemicals in Commerce, Product Details of C5H13Cl2N, the publication is Regulatory Toxicology and Pharmacology (2000), 32(2), 219-225, database is CAplus and MEDLINE.
It has been estimated that there are approx. 80,000 chems. in commerce. Thus, it is not possible to test all these substances for mutagenicity and carcinogenicity; it is possible, however, to test or make estimates from selected subsets of these chems. For example, in the U.S. National Toxicol. Program (NTP), 35% of the chems. tested for mutagenicity in Salmonella were pos., as were 52% of the chems. tested for carcinogenicity in rodents. In contrast, in the U.S. EPA Gene-Tox database, the proportions of chems. that are Salmonella mutagens is 56%. These and other databases may be biased toward pos. responses because they generally have been developed to look at specific structural or use classes of chems. or chems. suspected of genetic or carcinogenic activity. To address the question of the proportions of mutagens among all chems. in commerce, a database of 100 chems. was created from a random selection of chems. in commerce. These chems. were tested for mutagenicity in Salmonella and 22% were mutagenic. The mutagenicity of the 46 highest U.S. production organic chems. was also compiled; 20% were mutagenic. These values provide a more accurate estimate of the proportions of mutagens among chems. in commerce than can be derived from published mutagenicity databases. (c) 2000 Academic Press.
Regulatory Toxicology and Pharmacology published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C6H4KNO6S, Product Details of C5H13Cl2N.
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