Takahashi, Hidehiko published the artcileChemical aspects of plateau formation in the action current of the myelinated nerve fiber, Product Details of C7H16ClNO2, the publication is Japan. J. Physiol. (1960), 280-91, database is CAplus.
Among simple oxidizing agents, only H2O2 at concentrations higher than 2% produced a plateau in toad single myelinated nerve fibers in the temporal course of action current. Its effect was mainly due to hypertonicity, but its oxidizing potency was somewhat favorable to plateau formation. p-Quinone depolarized the Ranvier’s node and delayed the repolarization phase at the same time. Although recovery with the addition of cysteine was not so good, its effect was essentially attributable to its oxidizing potency, for hydroquinone at high concentrations caused deterioration. In the plasma membrane of the Ranvier’s node, the repolarization phase of action potential can be delayed most effectively by the –S–M–S– linkage (M represents bivalent transition metals).
Japan. J. Physiol. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C6H8N2, Product Details of C7H16ClNO2.
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