Prajapati, Neelam P. published the artcileThiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study, SDS of cas: 3696-23-9, the publication is Journal of Molecular Structure (2019), 401-410, database is CAplus.
In the present study, series of novel compounds (E)-2-(1-(4-methyl-2-(substituted-phenylamino)thiazol-5-yl)ethylidene)hydrazinecarbothio-amide I (R1 = H, 3-Me, 4-MeO, etc.; R2 = H, cyclohexyl) and (E)-N-cyclohexyl-2-(1-(4-methyl-2-(substituted-phenylamino)thiazol-5-yl)ethylidene)hydrazinecarbothioamide II have been synthesized using microwave irradiation method in high yields. Synthesized compounds were evaluated for their in-vitro antimicrobial, antimalarial and anti-tuberculosis activity as well as in-silico study. The obtained results indicate that compound II (R1 = 3-Me; R2 = cyclohexyl) and II (R1 = 4-OH; R2 = cyclohexyl) were found to be the most potent against S. aureus bacterial strain. Further, the mol. docking study has been performed for all the new compounds with the immune system of S. aureus (PDB ID: 5D1Q) as a target enzyme, and this study validated the exptl. results.
Journal of Molecular Structure published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.
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