Koolpe, Gary A. published the artcileDiastereomeric 6-desoxy-6-spiro-α-methylene-γ-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted Michael acceptor ligand, Quality Control of 5034-06-0, the publication is Journal of Medicinal Chemistry (1984), 27(12), 1718-23, database is CAplus and MEDLINE.
The title compounds I and II (R = Me or cyclopropylmethyl) were prepared by sequence reaction starting with direct alkylation of the diacetate ester of the parent ketone by the Reformatskii reagent prepared from Me α–(bromomethyl)acrylate [4224-69-5], and their affinity for opioid binding sites was determined in crude rat brain membrane preparation by competition against [3H]naltrexone in presence and absence of Na+. 6α–(2-Carboxyallyl)-17-(cyclopropylmethyl)-4,5α-epoxy-3,6β,14-trihydroxymorphinan-γ-lactone (II; R = cyclopropylmethyl) [92398-30-6] was the most potent compound showing a 50% inhibition of binding at 5 nM. The data suggest a receptor nucleophile such as SH is located where it can add to the α,β-unsaturated carbonyl system of the above compound
Journal of Medicinal Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Quality Control of 5034-06-0.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics