Kikuchi, Mikio published the artcilePredicting changes in aquatic toxicity of chemicals resulting from solvent or dispersant use as vehicle, Application of 3-Chloro-4-fluoronitrobenzene, the publication is Chemosphere (2016), 34-39, database is CAplus and MEDLINE.
The influence of two vehicles (N,N-dimethylformamide [DMF] as solvent and polyoxyethylene hydrogenated castor oil [HCO-40] as a dispersant) on the acute toxicity of eight hydrophobic chems. with a non-specific mode of action to Daphnia magna was investigated according to the OECD Guidelines for the Testing of Chems., Number 202. An increased 48-h EC50 value for D. magna or reduced toxicity resulting from the addition of HCO-40 to the test medium was observed for five of the eight chems. examined Each of eight chems. was dissolved in water at a concentration of either 10 mg/L or 1.0 mg/L, with or without DMF or HCO-40. Silicone film as a model of a biol. membrane was then immersed in each solution, and the concentration of each chem. in the water was monitored until equilibrium was reached for each test substance, after which the adsorbed amount of each chem. was determined The amounts of p-pentylphenol and four other substances with log Pow (1-octanol/water partition coefficient) values greater than 3.4 adsorbed onto the silicone film decreased with increasing concentrations of HCO-40. However, 3-chloro-4-fluoronitrobenzene and two other substances with log Pow values less than 2.6 demonstrated no changes in adsorption with either increasing HCO-40 concentration or the addition of DMF. The reduced adsorption in the presence of a vehicle on the silicone film correlated closely with changes in toxicity. These results indicate that the methodol. developed in this study enables the prediction of changes in toxicity resulting from the addition of vehicles to a test system.
Chemosphere published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application of 3-Chloro-4-fluoronitrobenzene.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics