D’Onofrio, Jennifer published the artcileAn Efficient and Versatile Solid-Phase Synthesis of 5′- and 3′-Conjugated Oligonucleotides, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Organic Letters (2005), 7(22), 4927-4930, database is CAplus and MEDLINE.
An easy and efficient solid-phase strategy to obtain 5′- and 3′-oligonucleotide conjugates in highly pure form has been developed. Ad hoc derivatized solid supports, to which the first nucleoside unit can be attached through a phosphate linkage, have been exploited both in a pre- and post-DNA assembly conjugation approach. A number of 5′- or 3′- oligonucleotide conjugates, incorporating a variety of labels covalently linked through a phosphodiester or a phosphoramidate bond, have been synthesized and characterized.
Organic Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Application of 3-Chloro-4-hydroxyphenylacetic acid.
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https://en.wikipedia.org/wiki/Chloride,
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