Boyd, G. S. published the artcileThe interrelations and effects of iodothyronines and cholesterol on the myocardium of the rat, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Atherosclerosis Research (1961), 470-88, database is CAplus and MEDLINE.
3,3′,5-Triiodo-L-thyronine (T3) was administered to adult male rats at 50 γ/day. Serum cholesterol, O consumption, heart rate, and histology of the heart were studied in these animals. The hyperthyroid state in the rat was accompanied by an increase in O consumption, heart rate, and cardiac hypertrophy. Many of the hearts from hyperthyroid rats exhibited degenerative lesions of the cardiac muscle characterized by focal necrosis and fibrosis. The effect of varying the diet on the metabolic and histol. responses was studied. The inclusion of cholesterol and olive oil in the diet appeared to protect the animal against T3-induced myocardial lesions. The time-course of these lesions with respect to the cardiac hypertrophy suggests that the effects may be causally related. The lesions can be produced by a wide variety of iodothyronines related to T3, provided the dosage of the analog is adjusted to produce an approx. equivalent cardiac hypertrophy.
Journal of Atherosclerosis Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
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