Li, Yangyang published the artcileModular access to substituted cyclohexanes with kinetic stereocontrol, HPLC of Formula: 939-99-1, the publication is Science (Washington, DC, United States) (2022), 376(6594), 749-753, database is CAplus and MEDLINE.
Substituted six-membered cyclic hydrocarbons are common constituents of biol. active compounds Although methods for the synthesis of thermodynamically favored, disubstituted cyclohexanes are well established, a reliable and modular protocol for the synthesis of their stereoisomers is still elusive. Herein, the authors report a general strategy for the modular synthesis of disubstituted cyclohexanes with excellent kinetic stereocontrol from readily accessible substituted methylenecyclohexanes by the implementation of chain-walking catalysis. Mechanistically, the initial introduction of a sterically demanding B ester group adjacent to the cyclohexane is key to guiding the stereochem. outcome. The synthetic potential of this methodol. was highlighted in late-stage modification of complex bioactive mols. and in comparison with current cross-coupling techniques.
Science (Washington, DC, United States) published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics