Josa-Cullere, Laia published the artcileA Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo, Synthetic Route of 209919-30-2, the publication is Journal of Medicinal Chemistry (2021), 64(21), 15608-15628, database is CAplus and MEDLINE.
Induction of differentiation is a promising therapeutic strategy against acute myeloid leukemia. However, current differentiation therapies are effective only to specific patient populations. To identify novel differentiation agents with wider efficacy, authors developed a phenotypic high-throughput screen with a range of genetically diverse cell lines. From the resulting hits, one chem. scaffold was optimized in terms of activity and physicochem. properties to yield OXS007417 I, a proof-of-concept tool compound, which was also able to decrease tumor volume in a murine in vivo xenograft model.
Journal of Medicinal Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Synthetic Route of 209919-30-2.
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