Ashraf, Muhammad Awais published the artcileSustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl- and allyl-substituted tert-alcohols, COA of Formula: C8H4ClF3O, the publication is iScience (2021), 24(12), 103388, database is CAplus and MEDLINE.
Trifluoromethylated mols. have gained privileged recognition among the medicinal and pharmaceutical chemists. Sustainable photoredox- and electrochem. processes were employed to facilitate the relatively less explored radical cross-electrophile coupling to access trifluoromethyl- and allyl-substituted tert-alcs. I (Ar = Ph, 2-ClC6H4, 2-naphthyl, etc.). Reactions proceed through trifluoromethyl ketyl radical and allyl radical intermediates, which underwent challenging radical-radical cross-coupling. The developed transformations are mild and chemo-selective to give cross-coupled products and deliver a wide range of valuable trifluoromethyl- and allyl-containing tertiary alcs. Both processes can also be applied for the synthesis of amine variant containing trifluoromethyl and allyl moiety, which is considered as amide bioisostere.
iScience published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics