Watanabe, Hitoshi published the artcileIdentification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors, Category: chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127911, database is CAplus and MEDLINE.
Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors. We hypothesized that brain penetration of NDMC differed from individual to individual, and highly permeable individuals may be responders, leading to M1 agonism. In order to demonstrate the Clozapine M1-hypothesis, we considered the following profile to be required: (i) robust M1 agonism, (ii) clozapine-like binding affinity toward various GPCRs, (iii) diminish or reduce reactive metabolite for-mation, (iv) no or weak M3 agonism, and (v) high brain permeability.
Bioorganic & Medicinal Chemistry Letters published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C9H4F6O, Category: chlorides-buliding-blocks.
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Chlorides – an overview | ScienceDirect Topics