Raddatz, Peter’s team published research in Journal of Medicinal Chemistry in 34 | CAS: 6249-56-5

Journal of Medicinal Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Raddatz, Peter published the artcileSubstrate analog renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (1991), 34(11), 3267-80, database is CAplus and MEDLINE.

Title analogs, e.g. I [Boc = Me3CO2C; X = Gly, β-Ala, NH(CH2)3CO, Ala], II, and III [X1 = COCH2CH2CO, (S)-CH(OH)CH2CH2CO, (R)-CH(OH)CH2CH2CO, COCH2SCH2CO, (S)-CH(OH)CH2SCH2CO, (R)-CH(OH)CH2SCH2CO, COCH2SOCH2CO, COCH2SO2CH2CO], were prepared as renin inhibitors. Oral activity was achieved by incorporation of polar functionalities at the N-terminus of β-alanine-containing tetrapeptides.

Journal of Medicinal Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics