Park, Jihye published the artcileControlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal-Organic Frameworks, Category: chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2016), 55(25), 7188-7193, database is CAplus and MEDLINE.
Development of a photosensitizing system that can reversibly control the generation of singlet oxygen (1O2) is of great interest for photodynamic therapy (PDT). Recently several photosensitizer-photochromic-switch dyads were reported as a potential means of the 1O2 control in PDT. However, the delivery of such a homogeneous mol. dyad as designed (e.g., optimal molar ratio) is extremely challenging in living systems. Herein we show a Zr-MOF nanoplatform, demonstrating energy transfer-based 1O2 controlled PDT. Our strategy allows for tuning the ratios between photosensitizer and the switch mol., enabling maximum control of 1O2 generation. Meanwhile, the MOF provides proximal placement of the functional entities for efficient intermol. energy transfer. As a result, the MOF nanoparticle formulation showed enhanced PDT efficacy with superior 1O2 control compared to that of homogeneous mol. analogs.
Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Category: chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics