Attimarad, Mahesh Veerabhadra published the artcileMicrowave assisted synthesis, pharmacological activities, and molecular docking studies of ethyl 2-[2-substituted-4-(thiophenyl) thiazolyl] acetates, Application In Synthesis of 3696-23-9, the publication is Iranian Journal of Pharmaceutical Research (2017), 16(4), 1379-1395, database is CAplus.
Two series of Et 2-[2-anilino-4-(2-thienyl)thiazol-5-yl]acetates I [R = 3-MeC6H4, 4-MeOC6H4, 4-BrC6H4, etc.] and Et 2-[2-(2-benzylidenehydrazino)-4-(2-thienyl)thiazol-5-yl]acetates II [R1 = 2-HOC6H4, 4-ClC6H4, 4-Me2NC6H4] were synthesized and screened for their anti-inflammatory, analgesic and antioxidant activities. In-vivo test results showed that the compounds I [R1 = 4-FC6H4, 4-ClC6H4, 3-Cl-4-FC6H3, 2,4-Cl2C6H3, 4-BrC6H4] exhibited good anti-inflammatory and analgesic activities, similar to that of indomethacin and aspirin, resp. Compounds II showed better anti-oxidant activity than compounds I when compared to ascorbic acid. Further, a mol. docking study was performed to predict the possible binding modes on cyclooxygenase-1 (COX-1) and COX-2 for compounds I and II. Good correlation was observed between the anti-inflammatory activity of the compounds I and II and the results of the binding modes in COX-2.
Iranian Journal of Pharmaceutical Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics