The genotoxicity of selected heterocyclic nitrogen compounds. A quantitative structure-activity relationship study was written by Zhu, C. M.;Kong, L. R.;Shen, Q. L.;Zhang, M.;Chen, J. W.;Huang, Q. G.;Wang, L. S.. And the article was included in Toxicological and Environmental Chemistry in 1998.Recommanded Product: 2272-40-4 The following contents are mentioned in the article:
The genotoxicity of heterocyclic N compounds was evaluated by micronuclei test of Vicia faba root tip cell. All these chems. are genotoxic. A meaningful Quant. Structure-Activity Relationship (QSAR) model was proposed by the quantum chem. descriptors: MN = -0.467-3.198 Elumo + 9.732q+. The above equation is significant because of its great RE and F values. It may reveal the mutagenic mechanism to some extent and can be used to describe the genotoxicity of 13 tested chems. The main key steps are metabolic course and mutagenic reaction. The chem. with higher q+ and lower Elumo has greater genotoxicity. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics