Catalyst and additive free 6-endo-dig cyclization of ortho-alkynylarylaldimines in water: An environmentally friendly access to isoquinolines was written by Yang, Jin;Wei, Xinyu;Yu, Yajun;Zhu, Yeting;Zhao, Yun-Hui;Xie, Wenlin;Zhao, Lang. And the article was included in Tetrahedron Letters in 2020.Related Products of 1186603-47-3 The following contents are mentioned in the article:
A novel and sustainable route for the synthesis of isoquinolines I (R1 = 7-OCH3, 7-Me, 7-Cl, 6-F; R2 = 4-methoxyphenyl, 3-chlorophenyl, Bu, etc.) was developed by reacting 2-ethynylbenzaldehydes 2-R2CC-R3C6H3CHO (R3 = 5-MeO, 5-Me, 5-Cl, H, 4-F) with ammonium hydroxide in water. This method provides a convenient, atom-economical, and catalyst-free access to diversely substituted isoquinolines with moderate to good yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Related Products of 1186603-47-3).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 1186603-47-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics