Catalytic Asymmetric Tandem Reaction of o-Alkynylbenzaldehydes, Amines, and Diazo Compounds was written by Wu, Wei;Liao, Na;Wei, Qi;Huang, Jiaying;Huang, Qi;Peng, Yungui. And the article was included in Organic Letters in 2021.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
An efficient asym. tandem reaction of o-alkynylbenzaldehydes, amines, and diazo compounds catalyzed by chiral silver imidodiphosphate has been established. Chiral 1,2-dihydroisoquinoline analogs have a tertiary stereocenter at the C1 position, and substituents at the C3 position are available with up to 97% yields and 98% ee. These products can be elaborated into the corresponding β-aminophosphonates or PARP1-inhibitor analogs. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics