Metal-/solvent-free oxidative [4 + 2]/[3 + 2] annulation of 2-ethynylbenzaldehydes with arylalkenes: facile synthesis of benzo[a]fluoren-5-ones was written by Wang, Cheng-Yong;Yu, Jiang-Xi;Liu, Bang;Zhang, Fu-Xing;Wang, Zhi-Qiang;Hu, Qin-Yu;Xu, Zhi-Feng;Li, Jin-Heng. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
A DTBP-mediated oxidative [4 + 2]/[3 + 2] annulation was reported between 2-alkynylbenzaldehydes and terminal arylalkenes enabled by aldehyde C(sp2)-H functionalization for assembling a range of benzo[a]fluoren-5-ones, e.g., I, with high step-economy, simple operation under metal-/solvent-free conditions and excellent functional group tolerance. This method was initiated from 2-alkynylbenzaldehyde reaction partners and provides a useful new strategy to construct complex benzo[a]fluoren-5-one scaffolds compared to existing protocols initiating from alkene reaction partners. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics