PROTAC-mediated crosstalk between E3 ligases was written by Steinebach, Christian;Kehm, Hannes;Lindner, Stefanie;Vu, Lan Phuong;Koepff, Simon;Lopez Marmol, Alvaro;Weiler, Corinna;Wagner, Karl G.;Reichenzeller, Michaela;Kroenke, Jan;Guetschow, Michael. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:
Small-mol. heterobifunctional degraders can effectively control protein levels and are useful research tools. We assembled proteolysis targeting chimeras (PROTACs) from a cereblon (CRBN) and a von-Hippel-Lindau (VHL) ligase ligand and demonstrated a PROTAC-induced heterodimerization of the two E3 ligases leading to unidirectional and efficient degradation of CRBN. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 1-Bromo-6-chlorohexane
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics