Gold-Catalyzed Bicyclic Annulations of 2-Alkynylbenzaldehydes with Vinyldiazo Carbonyls that Serve as Five-atom Building Units was written by Raj, Antony Sekar Kulandai;Liu, Rai-Shung. And the article was included in Angewandte Chemie, International Edition in 2019.Synthetic Route of C15H9ClO The following contents are mentioned in the article:
In the presence of (PhO)3PAuCl and AgOTf, α-diazo-β,γ-unsaturated ketones such as H2C:CHC(:N2)COPh underwent diastereoselective cyclization reactions with ortho-alkynylbenzaldehydes such as 2-(phenylethynyl)benzaldehyde to yield tetrahydrobenzindazoles such as I in which five atoms of the diazo compound are incorporated into the product. Mechanistic experiments provided evidence for a mechanism involving the initial [5+4]-cycloaddition of a benzopyrylium intermediate and a vinyldiazoketone followed by 6π-electrocyclization. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Synthetic Route of C15H9ClO).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C15H9ClO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics