Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents was written by Kumar, Ashok;Srivastava, Kumkum;Raja Kumar, S.;Puri, S. K.;Chauhan, Prem M. S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Related Products of 2272-40-4 The following contents are mentioned in the article:
The emergence and rapid spread of chloroquine resistant strains of Plasmodium falciparum has dramatically reduced the chemotherapeutic options. Towards this goal, a series of new class of hybrid 4-aminoquinoline triazines were synthesized and screened against CQ sensitive strain 3D7 of P. falciparum in an in vitro model. Compounds I and II exhibited more than 99% suppression on day 4 and on day 6 post treatment, compound II showed impressive 99.11% suppression against CQ resistant strain N-67 of P. yoelii in an in vivo assay. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics