Tetrabutylammonium bromide-catalyzed tandem addition-cyclization of o-aralkynylaryl aldehydes with trimethyl(trifluoromethyl)silane. Synthesis of trifluoromethyl group-containing phthalans was written by Hu, Bo-Lun;Li, Chun-Lin;Liao, Zhi-Yong;Zhang, Xing-Guo. And the article was included in Synlett in 2013.HPLC of Formula: 1186603-47-3 The following contents are mentioned in the article:
A Bu4NBr-catalyzed trifluoromethylation-cyclization reaction of o-aralkynylaryl aldehydes with Me3SiCF3 and CsF was developed. A variety of 1-alkylidene-3-(trifluoromethyl)phthalans were prepared in moderate to excellent yields by tandem nucleophilic addition and cyclization. The configuration of the product (1Z)-1-(4-chlorobenzylidene)-3-(trifluoromethyl)-1,3-dihydro-2-benzofuran was unambiguously confirmed by single-crystal X-ray diffraction anal. and its data were deposited at the Cambridge Crystallog. Data Center as supplementary publication number CCDC 968707. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3HPLC of Formula: 1186603-47-3).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 1186603-47-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics