Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis was written by Gustafson, Gary R.;Baldino, Carmen M.;O’donnell, Mary-Margaret E.;Sheldon, Adrian;Tarsa, Robert J.;Verni, Christopher J.;Coffen, David L.. And the article was included in Tetrahedron in 1998.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:
A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all, have been produced in 50μmol quantities using automated parallel solution phase synthesis. The use of this technol. in a search for protease inhibitors, glycopeptide surrogates and other bioactive compound classes will also be discussed. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics