Chemo-enzymatic approach to the synthesis of the antithrombotic clopidogrel was written by Ferraboschi, Patrizia;De Mieri, Maria;Galimberti, Fiorella. And the article was included in Tetrahedron: Asymmetry in 2010.Recommanded Product: 141109-14-0 The following contents are mentioned in the article:
The (S)-2-chlorophenylglycine moiety is well recognized in the structure of (S)-clopidogrel, a known antithrombotic drug. An enantiomerically pure chiral building block was prepared via an enzyme-catalyzed resolution of (RS)-N-Boc-2-chlorophenylglycine Me ester. The best results were obtained by means of an immobilized subtilisin, the cross-linked enzyme aggregate (Alcalase-CLEA). The high enantiomeric excess of the synthon obtained remained the same over the course of clopidogrel synthesis; the simplicity of the process makes this pathway suitable for large-scale preparation This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: 141109-14-0).
(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 141109-14-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics