Castanedo, Georgette M. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 53250-84-3

2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C7H6ClNO4S

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway was written by Castanedo, Georgette M.;Wang, Shumei;Robarge, Kirk D.;Blackwood, Elizabeth;Burdick, Daniel;Chang, Christine;Dijkgraaf, Gerrit J. P.;Gould, Stephen;Gunzner, Janet;Guichert, Oivin;Halladay, Jason;Khojasteh, Cyrus;Lee, Leslie;Marsters, James C. Jr.;Murray, Lesley;Peterson, David;Plise, Emile;Salphati, Laurent;de Sauvage, Frederic J.;Wong, Susan;Sutherlin, Daniel P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.COA of Formula: C7H6ClNO4S The following contents are mentioned in the article:

Potent and efficacious inhibitors of the hedgehog pathway for the treatment of cancer have been prepared using the 2-pyridyl biphenyl amide scaffold common to the clin. lead GDC-0449. Analogs with polar groups in the para-position of the aryl amide ring optimized potency, had minimal CYP inhibition, and possessed good exposure in rats. Compounds 9d and 14f potently inhibited hedgehog signaling as measured by Gli1 mRNA and were found to be equivalent or more potent than GDC-0449, resp., when studied in a Ptch+/- medulloblastoma allograft model, i.e., highly dependent on hedgehog signaling. This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3COA of Formula: C7H6ClNO4S).

2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C7H6ClNO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics