Thoma, William J. published the artcileEffect of vitamin C deficiency on hydroxylation of trimethylaminobutyrate to carnitine in the guinea pig, SDS of cas: 6249-56-5, the publication is Biochimica et Biophysica Acta, General Subjects (1984), 797(1), 136-9, database is CAplus and MEDLINE.
The effect of ascorbate [50-81-7] deficiency on carnitine [541-15-1] biosynthesis was investigated in young male guinea pigs. Liver and skeletal muscle carnitine levels were reduced in scorbutic animals. Heart and kidney concentrations remained unchanged. 14C-labeled 4-N-trimethylaminobutyrate [407-64-7] was administered to controls, pair-fed, and scorbutic animals and distribution of isotope in compounds present in the liver after 30 min was determined Control and pair-fed animals converted trimethylaminobutyrate to carnitine faster than scorbutic animals. Injection of ascorbate with the [14C]trimethylaminobutyrate reversed the decline in trimethylaminobutyrate hydroxylase (EC 1.14.11.1) [56803-11-3] activity in scorbutic animals.
Biochimica et Biophysica Acta, General Subjects published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C9H5Cl2F3, SDS of cas: 6249-56-5.
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