Serrano, Jose S. published the artcileCompared efficacy of quinidine, GABA and N-trimethyl GABA upon a model of ventricular automaticity, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Methods and Findings in Experimental and Clinical Pharmacology (1983), 5(4), 251-4, database is CAplus and MEDLINE.
The effects of GABA [56-12-2], its quaternary derivative N-trimethyl-GABA [10329-41-6], and quinidine [56-54-2] were studied in a model of ventricular automaticity induced in the isolated ventricle of the rat. GABA showed low antiautomatic activity. N-Trimethyl-GABA and quinidine were, however, very effective drugs in the reduction of the automatic ventricular rate. The efficacies of the latter 2 drugs at 5 × 10-5 M were not significantly different. Thus, N-trimethyl-GABA has antiautomatic activity in this exptl. model similar to that of the classic antidysrhythmic drug quinidine.
Methods and Findings in Experimental and Clinical Pharmacology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C10H7NO3, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
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