Mahindra, Amit published the artcileAntiplasmodial activity of short peptide-based compounds, COA of Formula: C19H14Cl2, the publication is RSC Advances (2015), 5(29), 22674-22684, database is CAplus.
Three series of short peptide-based compounds were synthesized, which upon evaluation against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum in vitro, produced IC50 values ranging between 1.4-4.7 μg mL-1. Importantly, higher antimalarial activity against the drug-resistant strain of P. falciparum (W2) was observed for the tested peptides, indicating their potential in the treatment of drug-resistant malaria parasites. The lack of cytotoxicity in all tested peptides provides evidence of their safety profile. The selected peptides were evaluated in an enzymic inhibitory assay against plasmepsin II, a potential target for antiplasmodial activity, also indicated from the results of the mol. docking studies.
RSC Advances published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, COA of Formula: C19H14Cl2.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics