Li, Jia published the artcileDiscovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists, Related Products of chlorides-buliding-blocks, the publication is Chemical Biology & Drug Design (2018), 92(1), 1241-1254, database is CAplus and MEDLINE.
A novel series of thiophene-containing biaryl amide derivatives I (R1 = 4-FC6H4, 4-CF3OC6H4, 4-t-BuC6H4, etc.; R2 = 2-Me-4-ClC6H3, 3-Me-4-ClC6H3, 2,4,6-(Me)3) as glucagon receptor (GCGR) antagonists were designed and synthesized. Two compounds of this series, I (R1 = 4-CF3OC6H4; R2 = 2-Me-4-ClC6H3) and I (R1 = 4-t-BuC6H4; R2 = 2-Me-4-ClC6H3), exhibited good GCGR binding (IC50 = 6.1 and 4.4 μM, resp.) and cAMP functional activities (IC50 = 4.4 and 14.4 μM, resp.). The possible binding modes of above two compounds with GCGR were explored by mol. simulation.
Chemical Biology & Drug Design published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Related Products of chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics