Genc, Sertac published the artcileIridium-Catalyzed Alkylation of Secondary Alcohols with Primary Alcohols: A Route to Access Branched Ketones and Alcohols, Quality Control of 939-99-1, the publication is Journal of Organic Chemistry (2020), 85(14), 9139-9152, database is CAplus and MEDLINE.
Under borrowing hydrogen conditions, NHC-iridium(I) catalyzed the direct or one-pot sequential synthesis of α,α-disubstituted ketones RCOCH(CH2R1)CH2R2 [R = Ph, 2-naphthyl, 4-MeOC6H4, etc.; R1 = Ph, 1-naphthyl, n-heptyl, etc.; R2 = Ph, 1-naphthyl, 4-MeOC6H4, etc.] via the alkylation of secondary alcs. with primary alcs. was reported. Notably, the present approach provides a new method for the facile synthesis of α,α-disubstituted ketones and featured with several characteristics, including a broad substrate scope, using easy-to-handle alcs. as starting materials, and performing the reactions under aerobic conditions. Moreover, the selective one-pot formation of β,β-disubstituted alcs. PhCH(OH)CH(CH2R3)CH2R4 [R3 = Ph, n-heptyl; R4 = Ph, 4-MeC6H4, 4-BrC6H4] was achieved by the addition of an external hydrogen source to the reaction mixture
Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Quality Control of 939-99-1.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics