Biochemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.
Elssner, Thomas published the artcileIsolation, Identification, and Synthesis of γ-Butyrobetainyl-CoA and Crotonobetainyl-CoA, Compounds Involved in Carnitine Metabolism of E. coli, Product Details of C7H16ClNO2, the publication is Biochemistry (2000), 39(35), 10761-10769, database is CAplus and MEDLINE.
A still unknown low-mol.-mass cofactor essential for the activity of carnitine-metabolizing enzymes (e.g., L-carnitine dehydratase, crotonobetaine reductase) from E. coli has been purified to homogeneity from a cell-free extract of E. coli O44K74. The purity of the cofactor was confirmed by HPLC anal. Biosynthesis of the unknown compound was only observed when bacteria were cultivated anaerobically in the presence of L-carnitine or crotonobetaine. The determined properties, together with results obtained from UV-visible, 1H NMR, and mass spectrometry, indicate that the compound in question is a new CoA derivative The esterified compound was suggested to be γ-butyrobetaine – a metabolite of carnitine metabolism of E. coli. Proof of structure was performed by chem. synthesis. Besides γ-butyrobetainyl-CoA, a second new CoA derivative, crotonobetainyl-CoA, was also chem. synthesized. Both CoA derivatives were purified and their structures confirmed using NMR and mass spectrometry. Comparisons of structural data and of the chem. properties of γ-butyrobetainyl-CoA, crotonobetainyl-CoA, and the isolated cofactor verified that the unknown compound is γ-butyrobetainyl-CoA. The phys. and chem. properties of γ-butyrobetainyl-CoA and crotonobetainyl-CoA are similar to known CoA derivatives
Biochemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.
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