Wu, Bowen published the artcileDesign, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives, Recommanded Product: 3-Chlorobenzylchloride, the publication is Youji Huaxue (2020), 40(4), 978-987, database is CAplus.
A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC6H4, 4-FC6H4, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH2C6H4] showed the most potent antitumor activity against PC-3 cells with IC50 value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH2C6H4] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH2C6H4] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway.
Youji Huaxue published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H23BO2, Recommanded Product: 3-Chlorobenzylchloride.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics