Subiros-Funosas, Ramon published the artcileUse of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin, Category: chlorides-buliding-blocks, the publication is Biopolymers (2012), 98(2), 89-97, database is CAplus and MEDLINE.
The presence of low pKa N-hydroxylamines is beneficial in peptide chem. as they reduce some base-mediated side reactions. Here we evaluated the applicability and buffering capacity of Et 2-cyano-2-(hydroxyimino)acetate (Oxyma) in the prevention of aspartimide/piperidide formation and Pro-based overcoupling and compared it with the performance of HOBt and HOAt. In addition, the compatibility of these additives with the highly acid-labile 2-chlorotrityl chloride resin is examined © 2011 Wiley Periodicals, Inc. Biopolymers, 2011.
Biopolymers published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C4H6N2, Category: chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics