Shen, Kun published the artcileDesign and synthesis of twin drug with nNOS-PSD-95 interrupts and gabapentin, pregabalin, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Nanjing Yike Daxue Xuebao, Ziran Kexueban (2014), 34(10), 1441-1445, database is CAplus.
The compounds of twin drug with nNOS-PSD-95 interrupts and gabapentin, pregabalin were designed, and new drugs for the treatment of neuropathic pain were found. The nNOS-PSD-95 interrupts and gabapentin, pregabalin were connected to form amide. The analgesic effects of target compounds were evaluated by neuropathic pain model. All target compounds showed different degree analgesic effects in neuropathic pain, the analgesic effect of twin drug of nNOS-PSD-95 interrupts and gabapentin, pregabalin twin drug in neuropathic pain was stronger than that of single target drugs. Twin drug with nNOSPSD-95 interrupts and gabapentin, pregabalin may get a better analgesic effect than that of single target drugs in neuropathic pain.
Nanjing Yike Daxue Xuebao, Ziran Kexueban published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H8INO, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.
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https://en.wikipedia.org/wiki/Chloride,
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