Nayak, Sabita published the artcileDesign and Synthesis of (E)-4-(2-Phenyl-2H-chromen-3-yl)but-3-en-2-ones and Evaluation of their In Vitro Antimicrobial Activity, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Letters in Organic Chemistry (2015), 12(5), 352-358, database is CAplus.
2H-Chromene and its derivatives are an important class of organic compounds due to their wide range of biol. activities such as antimicrobial, antiviral, antiinflammatory and antitubercular agents. In the present work, we have synthesized ten new 2H-chromene derivatives [(E)-4-(2-phenyl-2H-chromen-3-yl)but-3-en-2-one and its substituted analogs] by aldol condensation of 2H-chromene-3-carbaldehydes with acetone. These products have been characterized by means of spectral data (1H, 13C, IR, Mass). The structure of (E)-4-(6,8-dichloro-2-phenyl-2H-chromen-3-yl)but-3-en-2-one was confirmed by X-ray anal. The compounds were evaluated for in vitro antimicrobial activity against two Gram pos. bacteria [Streptococcus mutans (MTCC 497) and Streptococcus pyogenes (MTCC 1926)] and three Gram neg. bacteria [Vibrio cholera (MTCC 3909), Shigella flexneri (MTCC 1457) and Salmonella enteric typhi (MTCC 1252)]. The obtained results from in vitro antimicrobial assays by the broth dilution method indicated that many of the compounds exhibited excellent activity against all the microorganisms in comparison to standard kanamycin.
Letters in Organic Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
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