Capuano, Ben published the artcileSynthesis and preliminary pharmacological evaluation of 4′-arylmethyl analogues of clozapine. I. The effect of aromatic substituents, Formula: C13H9ClN2O4, the publication is Australian Journal of Chemistry (2002), 55(9), 565-576, database is CAplus.
As part of a research program to develop compounds with mixed dopamine D4 and serotonin 5-HT2A antagonist activity with potential for the treatment of schizophrenia, the preparation of 8-chloro-11-[4-(phenylmethyl)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives I (R = H, Br, Cl, F, Me, OMe, CF3, OCF3, etc.) based on a structural modification of the atypical antipsychotic clozapine was reported. Corresponding 8-chloro-11-[4-[(1H-indol-3-yl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, bioisosteric 8-chloro-11-[4-[(pyridinyl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, 4-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1,2-benzenediol and 3-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1H-indol-5-ol were also prepared The chem. synthesis, structural characterization and pharmacol. evaluation of a series 4′-arylmethyl analogs of clozapine are described. Preliminary receptor binding data are presented, examining primarily the electronic and positional effects of substituents on the introduced arylmethyl group, and secondarily the nature of the aryl ring.
Australian Journal of Chemistry published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Formula: C13H9ClN2O4.
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