Month: November 2022

Synthesis and structure-activity study of fungicidal anilinopyrimidines leading to mepanipyrim (KIF-3535) as an anti-Botrytis agent was written by Nagata, Toshihiro;Masuda, Katsumi;Maeno, Shinichiro;Miura, Ichiro. And the article was included in Pest Management Science in 2004.SDS of cas: 2272-40-4 The following contents are mentioned in the article:

A series of 2-anilinopyrimidines was prepared and their fungicidal activities against Botrytis cinerea were examined The activity fell sharply with any substitution on the anilinobenzene ring. Substitutions at the 5-position of the pyrimidine ring greatly reduced the activity. Substituents such as chloro, methoxy, methylamino, Me or 1-propynyl were well tolerated at the 4- and 6-positions of the pyrimidine ring. Among these substituents, the combination of Me and 1-propynyl groups was the most favorable. 2-Anilino-4-methyl-6-(1-propynyl)pyrimidine (KIF-3535), which showed excellent activity and no significant phytotoxicity, was finally selected for development and has been given the common name mepanipyrim. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanistic insights of molecular metal polyselenides for catalytic hydrogen generation was written by Elliott, Alexander;McAllister, James;Masaityte, Liudvika;Segado-Centellas, Mireia;Long, De-Liang;Ganin, Alexey Y.;Song, Yu-Fei;Bo, Carles;Miras, Haralampos N.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Safety of Tetramethylammonium chloride The following contents are mentioned in the article:

Mol. metal chalcogenides have attracted great attention as electrocatalysts for the hydrogen evolution reaction (HER). However, efficient utilization of the active sites and catalytic performance modulation has been challenging. Here we explore the design of immobilized mol. molybdenum polyselenides [Mo₂O₂S₂(Se₂)(Sex)]^2- that exhibit efficient hydrogen evolution at low overpotential and stability over 1000 cycles. D. functional calculations provide evidence of a unimol. mechanism in the HER process via the exploration of viable reaction pathways. The discussed findings are of a broad interest in the development of efficient mol. electrocatalytic materials. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Safety of Tetramethylammonium chloride).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of Tetramethylammonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents was written by Templ, Johanna;Schnuerch, Michael. And the article was included in Journal of Organic Chemistry in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The use of Ph trimethylammonium iodide (PhMe₃NI) as an alternative methylating agent for introducing a CH₃ group in α-position to a carbonyl group was described. Compared to conventional methylating agents, quaternary ammonium salts had the advantages of being nonvolatile, noncancerogenic and easy-to-handle solids. This regioselective method was characterized by ease of operational setup, use of anisole as green solvent and yields alkylated aryl ketones RC(O)CH(R¹)R² [R = Ph, 4-BrC₆H₄, 3-MeOC₆H₄, etc.; R¹ = Me, Et, Bn; R² = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.] up to 85%. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Category: chlorides-buliding-blocks).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ag-Catalyzed difluorohydration of β-alkynyl ketones for diastereoselective synthesis of 1,5-dicarbonyl compounds was written by Zhu, Yi-Long;Wang, Ai-Fang;Du, Jian-Yu;Leng, Bo-Rong;Tu, Shu-Jiang;Wang, De-Cai;Wei, Ping;Hao, Wen-Juan;Jiang, Bo. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.SDS of cas: 1186603-47-3 The following contents are mentioned in the article:

A new catalytic difluorohydration of β-alkynyl ketones using NFSI as the fluorinating reagent was established, diastereoselectively furnishing a range of structurally diverse difluoride 1,5-dicarbonyl products through C(sp³)-H fluorination. Notably, the sterically encumbered tert-Bu functionality located at the α-position of the carbonyl group of β-alkynyl ketone substrates showed excellent diastereoselectivity (up to >99:1 dr). The reaction enabled multiple bond-forming events including two C(sp³)-F formation through Ag-catalysis to provide a highly efficient and practical method toward difluoride 1,5-dicarbonyls, some of which were successfully converted into difluorinated isoquinolines. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3SDS of cas: 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coloration of fibrin fabric with berberine natural dye with ultrasonic technique using ZnO nano powder as light fastness improving was written by Kamel, M. M.;Mashaly, Hamada M.. And the article was included in World Applied Sciences Journal in 2013.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Berberine, a natural cationic colorant, is the major component of Amur Cork tree extract was used as a natural basic dye since the synthetic basic dyes remarked high acute and chronic toxicity on human beings, carcinogenic effect on animals, in addition to a hazardous effect on aquatic marines. These factors brightened the scope to carry out this research, by making a comparative dyeing study by ultrasonic and conventional heating techniques on anionized fibrin fabrics with the berberine dye. It is found that the performance of ZnO nano particles as UV-absorbers can be efficiently transferred to fabric materials. The UV tests indicate a significant improvement in the UV absorbing activity in the ZnO-treated fabrics. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An improved synthesis of clopidogrel bisulfate was written by Hu, Jia-peng;Lu, Xin;Liu, Zhi-bin. And the article was included in Zhejiang Huagong in 2012.Product Details of 141109-14-0 The following contents are mentioned in the article:

(S)-Me 2-amino-2-(2-chlorophenyl) acetate is obtained from racemic 2-amino-2-(2-chlorophenyl) acetic acid through esterification and optical resolution, which was subjected to condensation reaction with 2-(thiophen-2-yl)ethyl 4-Me benzene sulfonate to afford the critical intermediate (S)-Me 2-(2-chlorophenyl)-2-(2-thiophen-2-yl)ethylamino) acetate. The cyclization of (S)-Me 2-(2-chloropheny)-2-(2-(thiophen-2-yl) ethylamino) acetate with paraformaldehyde in the presence of anhydrous formic acid provided clopidogrel bisulfate. For this synthesis pathway, there are some advantages such as readily available starting material, moderate condition, high yield and good quality. This process is suitable for industrialization. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Product Details of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of highly active enzyme-metal nanohybrids and uncovering the design rules was written by Cheng, Guilin;Wu, Qi;Jiang, Chengjun. And the article was included in Enzyme and Microbial Technology in 2022.Application In Synthesis of Sodium tetrachloropalladate(II) The following contents are mentioned in the article:

Nanobiohybrid CAL-B/MNPs were synthesized through enzyme in situ reduction of metal ions, including noble and non-noble metals. Lipase CAL-B acted as multifunctional reagents (reducing and supporting agents). The hybrid catalysts were systematically characterized by HRTEM, EDX, MALDI-TOF-MS, and XPS anal., confirming that highly dispersed 3-5 nm nanoparticles were evenly dispersed on lipase matrix without agglomeration. The mechanism of CAL-B reducing metal ions was investigated, revealing that AGLFFSSKDL in the amino acid sequence of CAL-B from 111 to 128 formed a stable spatial structure through hydrogen bonding, which was the key factor for enzyme in situ reduction of metal ions into highly dispersed nanoparticles. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6Application In Synthesis of Sodium tetrachloropalladate(II)).

Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Sodium tetrachloropalladate(II)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anion-exchange Experiment of Zr, Hf, and Th in HNO₃ and Quantum Chemical Study on the Nitrate Complexes toward Chemical Research on Element 104, Rf was written by Watanabe, Eisuke;Kasamatsu, Yoshitaka;Yokokita, Takuya;Hayami, Sho;Tonai, Katsuma;Ninomiya, Hidemi;Kondo, Narumi;Shigekawa, Yudai;Haba, Hiromitsu;Kitagawa, Yasutaka;Nakano, Masayoshi;Shinohara, Atsushi. And the article was included in Solvent Extraction and Ion Exchange in 2022.Quality Control of N-Methyl-N,N-dioctyloctan-1-aminium chloride The following contents are mentioned in the article:

Anion-exchange behavior of Zr, Hf, and Th in nitric acid was investigated to determine suitable exptl. conditions for the experiment of element 104, rutherfordium (Rf) and to obtain comparative data for discussion of nitrate complexes of Rf. Anion-exchange reactions in a Adogen 464/HNO3 system was found to reach equilibrium within 60 s, suggesting that the reaction system is suitable for the experiment of 261Rf having a half-life of 68 s. We also studied the electronic states of Zr, Hf, and Th nitrate complexes by quantum chem. calculations The calculation results support the exptl. results that Th4+ forms stable anionic complexes such as [Th(NO3)6]2- with a large coordination number of 12, while Zr4+ and Hf4+ do not. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3Quality Control of N-Methyl-N,N-dioctyloctan-1-aminium chloride).

N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of N-Methyl-N,N-dioctyloctan-1-aminium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 4-(1H-isochromen-1-yl)isoquinolines through the silver-catalyzed homodimerization of ortho-alkynylarylaldehydes and subsequent condensation of the 1,5-dicarbonyl motif with NH₃ was written by Guo, Minghui;Meng, Xin;Zhao, Yang;Dong, Yuexia;Sun, Xuejun;Tian, Laijin;Cao, Ziping. And the article was included in RSC Advances in 2019.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

4-(1H-Isochromen-1-yl)isoquinoline derivatives I (R₁ = H, 7-OMe, 7-Cl, 6-Me, etc.; R₂ = C₆H₅, 4-MeC₆H₄, 3-FC₆H₄, 4-NCC₆H₄, etc.) were synthesized in high yields via the AgBF₄-catalyzed self-reaction of ortho-alkynylarylaldehydes to give isochromene intermediates, followed by the dehydration of the 1,5-dicarbonyl motif with NH₃. Compared with electron-rich aromatic substituents, this strategy can provide the desired isochromene products with an electron-deficient isoquinoline unit. The reactions feature simple exptl. operations, mild reaction conditions and high product yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of coumarin derivatives as anti-inflammatory agents was written by Kayal, Gaurav;Kayal, Snehlata;Gokhale, Niharika;Jain, Sanjay. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2016.Related Products of 95-88-5 The following contents are mentioned in the article:

All the newly synthesized Coumarin derivatives have shown considerable anti-inflammatory activity. In the present research work, we synthesized a series of novel Coumarin derivatives The Coumarin derivatives such as substituted 7-hydroxy-4-methyl-2H-chromen-2-one and substituted 6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one were synthesized from substituted benzoyl chloride. The chem. structures of the synthesized compounds were confirmed by means of IR and 1H-NMR. These compounds were screened for anti-inflammatory activity by carrageenan induced paw edema method in rats at a dose of 30 mg/kg body weight All the tested compounds of Coumarin derivatives were found to be more potent when compared to standard drug Diclofenac. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Related Products of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics