Month: November 2022

DBU/AgOTf Relay-Catalysis Enabled One-Pot Synthesis of 1,3-Dihydroisobenzofurans and Its Conversion to Indanones was written by Wang, Jiazhuang;Huang, Hongtai;Gao, Haotian;Qin, Guiping;Xiao, Tiebo;Jiang, Yubo. And the article was included in Advanced Synthesis & Catalysis in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

A DBU/AgOTf relay-catalyzed one-pot reaction of 2-alkynylbenzaldehydes and α-diazo esters for the efficient construction of 1,3-dihydroisobenzofuran derivatives was documented. This protocol can tolerate a wide range of substrates and its scalability was demonstrated by the gram-scale reaction. Moreover, the obtained 1,3-dihydroisobenzofurans were converted to indanone derivatives by a AgOTf-catalyzed ring recombination process. Both of the resulting products, 1,3-dihydroisobenzofurans and indanones, are important structural units of a variety of pharmaceuticals and natural products, and their structures are clearly confirmed by single crystal X-ray diffraction anal. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Category: chlorides-buliding-blocks).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates was written by Wang, Jane L.;Aston, Karl;Limburg, David;Ludwig, Cindy;Hallinan, Ann E.;Koszyk, Francis;Hamper, Bruce;Brown, David;Graneto, Matthew;Talley, John;Maziasz, Timothy;Masferrer, Jaime;Carter, Jeffery. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Reference of 89938-53-4 The following contents are mentioned in the article:

In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. We provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data. The challenge of a surprisingly long half-life (t _1/2 = 360 h) of the first clin. candidate 1 and human t _1/2 had been difficult to predict based on allometric scaling for this class of highly ppb compounds We used a microdose strategy which led to the discovery of clin. agents 18c-(S), 29b-(S), and 34b-(S) with human half-life of 57, 13, and 11 h. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Reference of 89938-53-4).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 89938-53-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry was written by Zhu, Chen;Yue, Huifeng;Rueping, Magnus. And the article was included in Nature Communications in 2022.Computed Properties of ClLi The following contents are mentioned in the article:

A three-component, reductive cascade, cross-coupling reaction for the arylalkylation of alkynes was reported. A wide range of trisubstituted alkenes were obtained in good to high yields with excellent chemo- and stereoselectivity by switching between electrochem. and photocatalysis. The E isomer of the product was obtained exclusively when the reaction was conducted with electricity and nickel, while the Z isomer was generated with high stereoselectivity when photo- and nickel dual catalysts were used. Moreover, photo-assisted electrochem. enabled nickel catalyzed protocol was demonstrated to selectively deliver Z-trisubstituted alkenes without the addition of photocatalysts. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Computed Properties of ClLi).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of ClLi

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Additive effects of lithium halides on the tensile and rheological properties of poly(methyl methacrylate) was written by Ito, Asae;Shin, Arisa;Nitta, Koh-hei. And the article was included in Polymer Journal (Tokyo, Japan) in 2022.Electric Literature of ClLi The following contents are mentioned in the article:

Lithium halides are easily dispersed in poly(Me methacrylate) (PMMA) and lead to strong phys. crosslinking with PMMA. We investigated the addnl. effects of various lithium halides, such as LiCl, LiBr, and LiI salts, on the rheol. and mech. properties of PMMA. The salts were homogeneously dispersed in the PMMA matrix, and the flow zone expanded owing to the pinning effects of the molten PMMA chains as the anion size increased. Furthermore, the brittleness of the PMMA solids doped with LiX (X = Cl, Br, and I) was analyzed using the Griffith theory, which suggested that the stress concentration around the salts in the PMMA matrix leads to the initiation of macroscopic fractures. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Electric Literature of ClLi).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of ClLi

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents was written by Solankee, Anjani;Kapadia, Kishor;Ciric, Ana;Sokovic, Marina;Doytchinova, Irini;Geronikaki, Athina. And the article was included in European Journal of Medicinal Chemistry in 2010.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:

Base-catalyzed condensation of a ketone with different aldehydes gave chalcones, 2.4-bis-(phenylamino)-6-[4′-{3”-(4”’-substituted phenyl/2”’-furanyl/2”’-thienyl)-2”-propenon-1”-yl}phenylamino]-s-thriazines. The chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammonium acetate give the corresponding acetylpyrazolines, aminopyrimidines, e.g., I (R = Cl, NO₂), and cyanopyridines, resp. All the four series of products were fully characterized by spectroscopic and elemental anal., and also tested for their antibacterial activity. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acyl Donors and Additives for the Biocatalytic Friedel-Crafts Acylation was written by Schmidt, Nina G.;Kroutil, Wolfgang. And the article was included in European Journal of Organic Chemistry in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

The Friedel-Crafts acylation is a broadly applied reaction that can be conducted using various types of catalyst. However, a biocatalytic alternative has only been reported recently. In this study, the scope of acetyl donors is described, showing that, in addition to vinyl acetate derivatives, Ph esters are also suitable donors. Furthermore, it was found that various amines enhance the reaction, whereby the effect do not seem to be correlated to the pH but to the structure of the donor. For instance, 1,4-diazabicyclo[2.2.2]octane (DABCO) turned out to be a viable alternative to imidazole; however the former performed best at pH 9.85, whereas the latter performed best at pH 8.3. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-Anilinoquinoline triazines: a novel class of hybrid antimalarial agents was written by Kumar, Ashok;Srivastava, Kumkum;Raja Kumar, S.;Siddiqi, M. I.;Puri, Sunil K.;Sexana, Jitendra K.;Chauhan, Prem M. S.. And the article was included in European Journal of Medicinal Chemistry in 2011.SDS of cas: 2272-40-4 The following contents are mentioned in the article:

A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as for their cytotoxicity toward VERO cell line. Five compounds exhibited the antimalarial potency superior to CQ. Compounds I and II were found to be orally active at a dose of 100 mg/kg × 4 days against CQ-resistant strain of P. yoelii. Inhibition of β-hematin formation assay and mol. docking study has been conducted in order to gain insight into the mechanism of action of proposed targets for the 4-anilinoquinoline and triazine moiety of the hybrid compounds This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A simple and convenient synthesis of 5-amino-substituted tetrazolo[1,5-a]-1,3,5-triazin-7-one salts was written by Parfenov, Victor E.;Bakharev, Vladimir V.;Zavodskaya, Anna V.;Selezneva, Eugenia V.;Gidaspov, Alexander A.;Suponitsky, Kyrill Yu.. And the article was included in Tetrahedron Letters in 2014.Related Products of 2272-40-4 The following contents are mentioned in the article:

A simple and convenient three-step synthesis of 5-amino-substituted tetrazolo[1,5-a]-1,3,5-triazin-7-one sodium salts I (NR¹R² = NH₂, NMe₂, NHPr-n, NHPr-iso, cyclohexyl, NHPh, NHC₆H₄Me-4, pyrrolidino, piperidino, morpholino) based on a fairly simple sequence of nucleophilic substitution of chlorine atoms in cyanuric chloride has been developed. The corresponding tetrabutylammonium salts were synthesized by cation-exchange with tetrabutylammonium chloride. The structures of the products were characterized by IR, ¹H NMR and ¹³C NMR spectroscopy, and by elemental and X-ray anal. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of substituted ureas possessing alkyl aromatic fragments via the reaction of 1-(3,3-diethoxypropyl)ureas with phenols was written by Smolobochkin, Andrey V.;Gazizov, Almir S.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Synthetic Communications in 2018.HPLC of Formula: 95-88-5 The following contents are mentioned in the article:

In this article, the approach to the substituted ureas based on the reaction of 1-(3,3-diethoxypropyl)ureas I [R¹ = R² = Me, i-Pr, Ph; R¹R² = (CH₂)₂O(CH₂)₂; R³ = R⁴ = OEt] with phenols was reported. Depending on the nature of the phenol and urea the reaction led either to diarylpropanes I [R³ = R⁴ = 5-Cl-2,4-di-HO-C₆H₂, 2,7-di-HO-1-naphthyl] and dibenzoxanthene derivatives or calixarenes. The proposed method benefited from mild reaction conditions, high product yields and operational simplicity. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5HPLC of Formula: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bronsted Acid-Promoted One-Pot Synthesis of Chrysene Derivatives via Isochromenylium Intermediate Formed in Situ was written by Guo, Biao;Zhou, Yiming;Zhang, Lei;Hua, Ruimao. And the article was included in Journal of Organic Chemistry in 2015.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

Trifluoromethanesulfonic acid (HOTf) promoted cross-coupling of ortho-[2-(4-methoxylphenyl)-alkynyl]acetophenones with ortho-alkynylbenzaldehydes affording chrysene derivatives I (R¹ = H, 2-F, 2-Cl, 2-Me, 3-F, etc.; R² = H, 3-Cl, 3-Me, 3-OMe, 2-F, 2-Cl, 1-F, etc.; R³ = H, Ph, 4-MeC₆H₄, 4-FC₆H₄, 4-ClC₆H₄) has been developed. The present cascade reaction provides a facile one-pot synthesis of multisubstituted chrysenes as well as naked chrysene under mild conditions. The mechanism exptl. results demonstrate isochromenylium is a key intermediate for this transformation. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics