Month: November 2022

Coppock, Matthew B.; Warner, Candice R.; Dorsey, Brandi; Orlicki, Joshua A.; Sarkes, Deborah A.; Lai, Bert T.; Pitram, Suresh M.; Rohde, Rosemary D.; Malette, Jacquie; Wilson, Jere A.; Kearney, Paul; Fang, Kenneth C.; Law, Scott M.; Candelario, Sherri L.; Farrow, Blake; Finch, Amethist S.; Agnew, Heather D.; Heath, James R.; Stratis-Cullum, Dimitra N. published an article in 2017, the title of the article was Protein Catalyzed Capture Agents with Tailored Performance for In Vitro and In Vivo Applications.Reference of tert-Butyl trichloroacetimidate And the article contains the following content:

We report on peptide-based ligands matured through the Protein Catalyzed Capture (PCC) agent method to tailor mol. binders for in vitro sensing/diagnostics and in vivo pharmacokinetics parameters. A Vascular Endothelial Growth Factor (VEGF) binding peptide and a peptide against the Protective Antigen (PA) protein of Bacillus anthracis discovered through phage and bacterial display panning technologies, resp., were modified with click handles and subjected to iterative in situ click chem. screens using synthetic peptide libraries. Each azide-alkyne cycloaddition iteration, promoted by the resp. target proteins, yielded improvements in metrics for the application of interest. The anti-VEGF PCC was explored as a stable in vivo imaging probe. It exhibited excellent stability against proteases and a mean elimination in vivo half-life (T1/2) of 36 min. I.p. injection of the reagent results in slow clearance from the peritoneal cavity and kidney retention at extended times, while i.v. injection translates to rapid renal clearance. The ligand competed with the com. antibody for binding to VEGF in vivo. The anti-PA ligand was developed for detection assays that perform in demanding phys. environments. The matured anti-PA PCC exhibited no solution aggregation, no fragmentation when heated to 100 oC, and a > 81% binding activity for PA after heating at 90°C for 1 h. We discuss the potential of the PCC agent screening process for the discovery and enrichment of next generation antibody alternatives. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Reference of tert-Butyl trichloroacetimidate

The Article related to vegf binding peptide pet imaging agent pharmacokinetics, biological stability, peptide, protective antigen, protein catalyzed capture agent, synthetic antibody, thermal stability, vascular endothelial growth factor and other aspects.Reference of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 1983, Fray, M. Jonathan; Thomas, Eric J.; Wallis, John D. published an article.HPLC of Formula: 5034-06-0 The title of the article was On the stereoselectivity of epoxide formation using dimethyloxosulfonium methylide. X-ray structure of (5SR)-5-[(1RS)-1-methyl-2-oxacyclopropyl]pyrrolidin-2-one. And the article contained the following:

Epoxidation of 5-acetylpyrrolidin-2-one with dimethyloxosulfonium methylide in THF at 20° for 2 h and then 55° for 1 h gave a 78:22 mixture of epoxides I (α-Me, β-Me) (II and III, resp.) whereas in the presence of ZnCl2 a 23:77 mixture of II and III was obtained. The configuration of these epoxides was determined from the NMR spectra of the corresponding carbonate derivatives IV and by x-ray crystallog. anal. of III. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).HPLC of Formula: 5034-06-0

The Article related to epoxidation acetylpyrrolidinone stereoselectivity, pyrrolidinone acetyl epoxidation stereoselectivity, methyloxiranylpyrrolidinone preparation configuration crystal structure, oxiranylpyrrolidinone methyl structure and other aspects.HPLC of Formula: 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 1, 2019, Gotoh, Kazuma; Ishida, Hiroyuki published an article.COA of Formula: C7H4ClNO4 The title of the article was Crystal structures of the two isomeric hydrogen-bonded cocrystals 2-chloro-4-nitrobenzoic acid-5-nitroquinoline (1/1) and 5-chloro-2-nitrobenzoic acid-5-nitroquinoline (1/1). And the article contained the following:

The structures of two isomeric compounds of 5-nitroquinoline with chloro- and nitro-substituted benzoic acid, namely, 2-chloro-4-nitrobenzoic acid-5-nitroquinoline (1/1), (I), and 5-chloro-2-nitrobenzoic acid-5-nitroquinoline (1/1), (II), both C7H4ClNO4·C9H6N2O2, have been determined at 190 K. In each compound, the acid and base mols. are held together by an O-H···N hydrogen bond. In the crystal of (I), the hydrogen-bonded acid-base units are linked by a C-H···O hydrogen bond, forming a tape structure along [1 [inline formula omitted] 0]. The tapes are stacked into a layer parallel to the ab plane via N-O···π interactions between the nitro group of the base mol. and the quinoline ring system. The layers are further linked by other C-H···O hydrogen bonds, forming a three-dimensional network. In the crystal of (II), the hydrogen-bonded acid-base units are linked into a wide ribbon structure running along [1 [inline formula omitted] 0] via C-H···O hydrogen bonds. The ribbons are further linked via another C-H···O hydrogen bond, forming a layer parallel to (110). Weak π-π interactions [centroid-centroid distances of 3.7080 (10) and 3.7543 (9) Å] are observed between the quinoline ring systems of adjacent layers. Hirshfeld surfaces for the 5-nitroquinoline mols. of the two compounds mapped over shape index and dnorm were generated to visualize the weak intermol. interactions. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to chloro nitrobenzoic acid nitroquinoline isomeric hydrogen bond crystal structure, 2-chloro-4-nitro­benzoic acid, 5-chloro-2-nitro­benzoic acid, 5-nitro­quinoline, hirshfeld surface, crystal structure, hydrogen bond and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 20, 2012, Uthuppu, Basil; Aamand, Jens; Joergensen, Claus; Kiersgaard, Spire M.; Kostesha, Natalie; Jakobsen, Mogens Havsteen published an article.Recommanded Product: Methyl 6-chloro-6-oxohexanoate The title of the article was Optimization of an immunoassay of 2,6-dichlorobenzamide (BAM) and development of regenerative surfaces by immunosorbent modification with newly synthesized BAM hapten library. And the article contained the following:

Dichlobenil is an extensively used herbicide worldwide which is transformed to the mobile 2,6-dichlorobenzamide (BAM) in soil. BAM has been found in many European groundwater resources that are exploited for drinking water. Currently, immunoassay based monitoring technique (plate based ELISA) is being employed to quant. detect BAM in water samples. As a starting step of developing immunoassay based on-site monitoring systems for pesticide anal., the heterogeneous BAM immunoassay is optimized in terms of surface (polymer) regeneration. We synthesized a small library of BAM haptens which are slightly different in chem. structures, immobilized them on surfaces and compared the affinity constants of the monoclonal antibody HYB 273 towards them. By using ELISA technol., we also checked the regeneration potentials of the haptens, correlated these results to the affinity constants and found that BAM hapten with an intermediate affinity has better regeneration potential. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: Methyl 6-chloro-6-oxohexanoate

The Article related to optimization immunoassay dichlorobenzamide regenerative surface immunosorbent modification synthesized hapten, immunoassay dichlorobenzamide regenerative surface immunosorbent modification synthesized hapten library and other aspects.Recommanded Product: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 27, 2022, Liu, Jingbo; Shi, Yabing; Tian, Zhicheng; Li, Fengyun; Hao, Zesheng; Wen, Wen; Zhang, Li; Wang, Yuanhong; Li, Yuxin; Fan, Zhijin published an article.Safety of 2-Amino-4-chlorobenzoic acid The title of the article was Bioactivity-Guided Synthesis Accelerates the Discovery of Evodiamine Derivatives as Potent Insecticide Candidates. And the article contained the following:

Pests threaten worldwide food security by decreasing crop yields and damaging their quality. Natural product-based mol. design and structural optimization have been one of the most effective ways to innovate pesticides for integrated insect management. To continue our previous studies on the discovery of insecticidal lead, a series of evodiamine derivatives were designed, synthesized, and evaluated for their insecticidal activities. The bioassay results demonstrated that compounds (I) and (II) exhibited 90 and 80% insecticidal activities against Mythimna separata at 2.5 mg/L, resp., which were superior to evodiamine (10% at 10 mg/L), matrine (45% at 600 mg/L), and rotenone (30% at 200 mg/L). Compounds I, II and (III) showed 90% insecticidal activities against Plutella xylostella at 1.0 mg/L, far more potent than those of evodiamine, matrine, and rotenone. Compound I displayed 60% insecticidal activity against Helicoverpa armigera at 5.0 mg/L, while evodiamine, matrine, and rotenone showed very poor activities. The study on the insecticidal mechanism of action by a calcium imaging experiment indicated that the insect ryanodine receptors (RyRs) could be the potential target of I. Furthermore, the mol. docking indicated that I anchored in the binding site of the RyR of P. xylostella. The above results manifested the potential of evodiamine derivatives as potent insecticide candidates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Safety of 2-Amino-4-chlorobenzoic acid

The Article related to evodiamine derivative preparation insecticide mythimna plutella helicoverpa ryanodine receptor, evodiamine, insecticidal activity, insecticidal mechanism of action, molecular docking, structure−activity relationship and other aspects.Safety of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Lei; Zhong, Jialing; Lin, Xufeng published an article in 2019, the title of the article was Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

An efficient organocatalytic atroposelective three-component cascade reaction of 2,3-diketoesters, aromatic amines, and 1,3-cyclohexanediones has been developed for the highly enantioselective synthesis of axially chiral N-arylindoles. The success of this method derives from the use of a newly developed second-generation chiral spirocyclic phosphoric acid as the catalyst. In addition, this protocol was extended to the synthesis of an axially chiral monophosphorus ligand. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to atroposelective phosphoric acid catalyst three component cascade reaction, enantioselective synthesis axially chiral arylindole, atroposelectivity, indoles, multicomponent reaction, organocatalysis, synthetic methods and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Roesner, Stefan; Saunders, George J.; Wilkening, Ina; Jayawant, Eleanor; Geden, Joanna V.; Kerby, Paul; Dixon, Ann M.; Notman, Rebecca; Shipman, Michael published an article in 2019, the title of the article was Macrocyclization of small peptides enabled by oxetane incorporation.Product Details of 98946-18-0 And the article contains the following content:

Cyclic peptides are an important source of new drugs but are challenging to produce synthetically. We show that head-to-tail peptide macrocyclizations are greatly improved, as measured by isolated yields, reaction rates and product distribution, by substitution of one of the backbone amide C:O bonds with an oxetane ring. The cyclization precursors are easily made by standard solution- or solid-phase peptide synthesis techniques. Macrocyclizations across a range of challenging ring sizes (tetra-, penta- and hexapeptides) are enabled by incorporation of this turn-inducing element. Oxetane incorporation is shown to be superior to other established amino acid modifications such as N-methylation. The positional dependence of the modification on cyclization efficiency is mapped using a cyclic peptide of sequence LAGAY. We provide the first direct exptl. evidence that oxetane modification induces a turn in linear peptide backbones, through the observation of dNN (i, i + 2) and dαN (i, i + 2) NOEs, which offers an explanation for these improvements. For cyclic peptide, cLAGAY, a combination of NMR derived distance restraints and mol. dynamics simulations are used to show that this modification alters the backbone conformation in proximity to the oxetane, with the flexibility of the ring reduced and a new intramol. H-bond established. Finally, we incorporated an oxetane into a cyclic pentapeptide inhibitor of Aminopeptidase N, a transmembrane metalloprotease overexpressed on the surface of cancer cells. The inhibitor, cCNGRC, displayed similar IC50 values in the presence or absence of an oxetane at the glycine residue, indicating that bioactivity is fully retained upon amide C:O bond replacement. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0

The Article related to cyclic peptide synthesis md simulation hydrogen bond safety, oxetane peptide coupling macrocyclization solid phase synthesis cyclization kinetics, peptide cyclic oxetane aminopeptidase n inhibiting structure activity and other aspects.Product Details of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 2, 2018, Patel, Nitinchandra D.; Sieber, Joshua D.; Tcyrulnikov, Sergei; Simmons, Bryan J.; Rivalti, Daniel; Duvvuri, Krishnaja; Zhang, Yongda; Gao, Donghong A.; Fandrick, Keith R.; Haddad, Nizar; Lao, Kendricks So; Mangunuru, Hari P. R.; Biswas, Soumik; Qu, Bo; Grinberg, Nelu; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Gupton, B. Frank; Garg, Neil K.; Kozlowski, Marisa C.; Senanayake, Chris H. published an article.Formula: C6H10Cl3NO The title of the article was Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis. And the article contained the following:

Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substituted biaryls leads to chiral atropisomeric products that introduce the opportunity to use catalyst control to develop asym. cross-coupling procedures to access these important compounds Asym. Pd-catalyzed Suzuki-Miyaura and Negishi cross-coupling reactions to form tetra-ortho-substituted biaryls were studied employing a collection of P-chiral dihydrobenzooxaphosphole (BOP) and dihydrobenzoazaphosphole (BAP) ligands. Enantioselectivities of up to 95:5 and 85:15 enantiomeric ratios were identified for the Suzuki-Miyaura and Negishi cross-coupling reactions, resp. Unique ligands for the Suzuki-Miyaura reaction vs the Negishi reaction were identified. A computational study on these Suzuki-Miyaura and Negishi cross-coupling reactions enabled an understanding in the differences between the enantiodiscriminating events between these two cross-coupling reactions. These results support that enantioselectivity in the Negishi reaction results from the reductive elimination step, whereas all steps in the Suzuki-Miyaura catalytic cycle contribute to the overall enantioselection with transmetalation and reductive elimination providing the most contribution to the observed selectivities. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Formula: C6H10Cl3NO

The Article related to computationally assisted mechanistic investigation, palladium catalyst asym suzuki miyaura negishi cross coupling, tetra ortho substituted biaryl synthesis, palladium, asymmetric, catalysis, cross-coupling, phosphines and other aspects.Formula: C6H10Cl3NO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 31, 2021, Navidpour, Latifeh; Shabani, Shabnam; Heidari, Alireza; Bashiri, Manouchehr; Ebrahim-Habibi, Azadeh; Shahhosseini, Soraya; Shafaroodi, Hamed; Abbas Tabatabai, Sayyed; Toolabi, Mahsa published an article.Recommanded Product: 99-60-5 The title of the article was 5-[Aryloxypyridyl (or nitrophenyl)]-4H-1,2,4-triazoles as novel flexible benzodiazepine analogues: Synthesis, receptor binding affinity and lipophilicity-dependent anti-seizure onset of action. And the article contained the following:

A new series of 5-(2-aryloxy-4-nitrophenyl)-4H-1,2,4-triazoles and 5-(2-aryloxy-3-pyridyl)-4H-1,2,4-triazoles, possessing C-3 thio or alkylthio substituents, was synthesized and evaluated for their benzodiazepine receptor affinity and anti-seizure activity. These analogs revealed similar to significantly superior affinity to GABAA/benzodiazepine receptor complex (IC50 values of 0.04-4.1 nM), relative to diazepam as the reference drug (IC50 value of 2.4 nM). To determine the onset of anti-seizure activity, the time-dependent effectiveness of i.p. administration of compounds on pentylenetetrazole induced seizure threshold was studied and a very good relationship was observed between the lipophilicity (cLogP) and onset of action of studied analogs (r2 = 0.964). The min. ED of the compounds, determined at the time the analogs showed their highest activity, was demonstrated to be 0.025-0.1 mg/kg, relative to diazepam (0.025 mg/kg). The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to triazol flexible benzodiazepine derivative preparation lipophilicity antiseizure activity, 1,2,4-triazole, flexible benzodiazepines, gabaa/benzodiazepine receptor complex, onset of action, ptz induced seizure threshold and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gong, Ya-Ping; Tang, Long-Qian; Liu, Tong-Shen; Liu, Zhao-Peng published an article in 2019, the title of the article was Synthesis and evaluation of novel 2H-benzo[e]-[1,2,4]thiadiazine 1,1-dioxide derivatives as PI3Kδ inhibitors.Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride And the article contains the following content:

The carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives I [R1 = H, F; R2 = Ph, 3-methoxyphenyl, 6-methoxypyridin-3-yl, 1H-indol-5-yl, etc.] as PI3Kδ inhibitors was replaced. After the reduction of nitro group in N-(2,6-dimethylphenyl)-2-nitrobenzenesulfonamide and N-(2,6-dimethylphenyl)-2-nitro-5-fluorobenzenesulfonamide, the resulting 2-aminobenzenesulfonamides were reacted with tri-Me orthoacetate to give the 3-methyl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives After bromination of the 3-Me group, the nucleophilic substitution with the 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine provided the resp. iodide derivatives, which were further reacted with a series of arylboronic acids via Suzuki coupling to furnish the 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives I. In agreement with the quinazolinone derivatives, the introduction of a 5-indolyl or 3,4-dimethoxyphenyl at the affinity pocket generated the most potent analogs I [R1 = H; R2 = 1H-indol-5yl, 3,4-dimethoxyphenyl] with the IC50 values of 217 to 266 nM, resp. In comparison with the quinazolinone lead compounds I these 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives exhibited much decreased PI3Kδ inhibitory potency, but maintained the high selectivity over other PI3K isoforms. Unlike the quinazolinone lead compound I that was a dual PI3Kδ/γ inhibitor, the benzothiadiazine 1,1-dioxide I [R1 = H; R2 = 3,4-dimethoxyphenyl] was more than 21-fold selective over PI3Kγ. Moreover, the introducing of a fluorine atom at the 7-position of the 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide core, I in general, was not favored for the PI3Kδ inhibitory activity. In agreement with their high PI3Kδ selectivity, I [R1 = H; R2 = 1H-indol-5yl, 3,4-dimethoxyphenyl] significantly inhibited the SU-DHL-6 cell proliferation. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

The Article related to pyrazolopyrimidinylmethyl dimethylphenyl benzothiadiazine dioxide preparation phosphatidylinositol kinase antitumor sar, 2h-benzo[e][1,2,4]thiadiazine 1,1-dioxide, pi3ks, pi3kδ inhibitors, anticancer, anticancer agents and other aspects.Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics