Month: November 2022

On August 25, 2011, Bregman, Howard; Buchanan, John L.; Chakka, Nagasree; Dimauro, Erin F.; Du, Bingfan; Nguyen, Hanh Nho; Zheng, Xiao Mei published a patent.Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride The title of the patent was Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. And the patent contained the following:

The present invention provides compounds I [X = NH, NMe, O, S; S, T and U = CR3, N; A = (hetero)aryl; R1 = H, alkyl, haloalkyl, etc.; R11 = H or alkyl; R2 = H, alkyl, aryl, etc.; R3 = H, halo, alkyl, etc.; R4 = H, alkyl, halo, etc.; R5 = H, alkyl, (hetero)aryl; R6 = (un)substituted (hetero)aryl, heterocyclyl, cycloalkyl, etc.; or NR5R6 = (un)substituted heteroaryl, heterocyclyl, bridged heterocyclyl, spiroheterocyclyl] that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. over three-hundred compounds I were prepared and formulated. thus, reacting 2,4-dichloro-1,3,5-triazine with 3-amino-2-methylbenzamide followed by treating the resulting 3-(4-chloro-1,3,5-triazin-2-ylamino)-2-methylbenzamide with 1-(3,4-dimethylphenyl)piperazine afforded II. compounds I were tested on human Nav1.7 expressed stably in 293 cells (data given). also provided are pharmaceutical compositions containing compounds I and processes for preparing such compounds The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride

The Article related to aryl carboxamide amide preparation analgesic sodium channel inhibitor, voltage gated sodium channel blocker aryl carboxamide amide preparation, chronic pain treatment aryl carboxamide amide preparation and other aspects.Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fernandez, Gabriela A.; Castro, Eliana F.; Rosas, Rocio A.; Fidalgo, Daniela M.; Adler, Natalia S.; Battini, Leandro; Espana de Marco, Maria J.; Fabiani, Matias; Bruno, Ana M.; Bollini, Mariela; Cavallaro, Lucia V. published an article in 2020, the title of the article was Design and optimization of quinazoline derivatives: new non-nucleoside inhibitors of bovine viral diarrhea virus.Application of 89-77-0 And the article contains the following content:

In a previous work, potential mols. that dock into an allosteric binding pocket of BVDV RdRp via a structure-based virtual screening approach was identified. One of them, N-(2-morpholinoethyl)-2-phenylquinazolin-4-amine I [R2 = Ph; R4 = 2-morpholinoethylamino; R7 = H] [50% effective concentration (EC50) = 9.7 ± 0.5μM], was selected to perform different chem. modifications. Among synthesized derivatives I [R2 = H, Ph, 4-MeC6H4, etc.; R4 = 4-methylpiperazin-1-yl, HN(CH2)5CH3, 4-methoxyanilino, etc.; R7 = H, Cl], compound I [R2 = H, Ph, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, (2-morpholinoethylamino), 2-(1-piperidyl)ethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino, ; R7 = H, Cl] of them showed considerable antiviral activity. Mol. modeling of the most active compounds I [R2 = H, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, 2-morpholinoethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino; R7 = H, Cl] showed that they bind to a pocket located in the fingers and thumb domains in BVDV RdRp, which was different than that identified for other non-nucleoside inhibitors (NNIs) such as thiosemicarbazone (TSC). Compound 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethanol I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] ( EC50 = 1.7 ± 0.4μM) was selected for further anal. Compound I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] was found to inhibit the in vitro replication of TSC-resistant BVDV variants, which carry the N264D mutation in the RdRp. In addition, I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] presented adequate solubility in different media and a high-stability profile in murine and bovine plasma. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to quinazolinyl amine preparation antiviral docking cytotoxicity pharmacokinetic stability, bvdv inhibitors, rdrp protein, molecular dynamics, pharmacokinetics in vitro properties, quinazoline derivatives and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 17, 2021, Li, Xiaoyu; Golden, Jennifer E. published an article.HPLC of Formula: 89-77-0 The title of the article was Construction of N-Boc-2-Alkylaminoquinazolin-4(3H)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity. And the article contained the following:

A multicomponent procedure integrating anthranilic acids, N-Boc-amino acids and amines in the presence of methanesulfonyl chloride, N-methylimidazole, and copper(II) chloride was developed to mildly afford N-Boc-2-alkylaminoquinazolin-4(3H)-ones, e.g., I, with excellent preservation of enantiomeric purity (>99% ee). Copper(II) chloride was essential to retaining enantiopurity and reaction component structural changes were well tolerated, resulting in an efficient, all-in-one procedure that promoted sequential coupling, lactonization, aminolysis and cyclization in good yields. The method was applied to the rapid assembly of four key intermediates used in the synthesis of high profile quinazolinones, including several PI3K inhibitor drugs. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).HPLC of Formula: 89-77-0

The Article related to boc alkylaminoquinazolinone preparation enantioselective, anthranilic acid amino aniline copper chloride mediated multicomponent, pi3 kinase, copper-mediated, enantiopurity, quinazolinone, racemization and other aspects.HPLC of Formula: 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 25, 1986, Matsuda, Akira; Ueda, Tohru published an article.Formula: C3H9ClOS The title of the article was Nucleosides and nucleotides. LXVI. Synthesis of 8,6′-cyclo-6′-deoxyhexofuranosyladenines: adenosines fixed in an anti-conformation. And the article contained the following:

For studies of the conformation of nucleosides around the glycosyl linkages, the carbon-bridged cycloadenosines I (R = OH, R1 = H; R = H, R1 = OH) were prepared by the following route. Treatment of N6-benzoyl-2′,3′-O-isopropylideneadenosine 5′-aldehyde with dimethyloxosulfonium methylide afforded the 5′,6′-anhydrohexofuranosyladenine II, which was treated with thiophenoxide to give the diastereomeric 6′-phenylthio derivatives III. Photoirradiation of III followed by 5′-O-acetylation afforded III. Attempted synthesis of a 8,7′-cycloheptofuranosyl derivative by way of photolysis of a 7′-phenylthioheptofuranosyladenine resulted in the formation of 5′,6′,7′-trideoxy-2′,3′-O-isopropylidene-β-D-ribo-heptofuranosyladenine. The nature of the CD spectra of I is discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Formula: C3H9ClOS

The Article related to cyclo deoxyhexofuranosyladenine, carbon bridged cycloadenosine, nucleoside carbon bridged cyclo, cd cyclo deoxyhexofuranosyladenine, conformation nucleoside, photochem cyclization phenylthio nucleoside and other aspects.Formula: C3H9ClOS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 16, 2021, Abad-Galan, Laura; Cieslik, Patrick; Comba, Peter; Gast, Michael; Maury, Olivier; Neupert, Lucca; Roux, Amandine; Wadepohl, Hubert published an article.Category: chlorides-buliding-blocks The title of the article was Excited State Properties of Lanthanide(III) Complexes with a Nonadentate Bispidine Ligand. And the article contained the following:

EuIII, TbIII, GdIII and YbIII complexes of the nonadentate bispidine derivative L2 (bispidine=3,7-diazabicyclo[3.3.1]nonane) were successfully synthesized and their emission properties studied. The X-ray crystallog. reveals full encapsulation by the nonadentate ligand L2 that enforces to all LnIII cations a common highly sym. capped square antiprismatic (CSAPR) coordination geometry (pseudo C4v symmetry). The well-resolved identical emission spectra in solid state and in solution confirm equal structures in both media. As therefore expected, this results in long-lived excited states and high emission quantum yields ([EuIIIL2]+, H2O, 298 K, τ=1.51 ms, φ=0.35; [TbIIIL2]+, H2O, 298 K, τ=1.95 ms, φ=0.68). Together with the very high kinetic and thermodn. stabilities, these complexes are a possible basis for interesting biol. probes. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks

The Article related to lanthanide nonadentate bispidine complex preparation luminescence, crystal structure lanthanide nonadentate bispidine complex, lanthanides, luminescence, nonadentate ligand, photophysics, quantum yield and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rodriguez-Aristegui, Sonsoles; Clapham, Kate M.; Barrett, Lauren; Cano, Celine; Desage-El Murr, Marine; Griffin, Roger J.; Hardcastle, Ian R.; Payne, Sara L.; Rennison, Tommy; Richardson, Caroline; Golding, Bernard T. published an article in 2011, the title of the article was Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.Related Products of 38939-88-7 And the article contains the following content:

Amino-substituted biphenyls were obtained by Suzuki cross-coupling of 2,6-dibromoaniline with a phenylboronic acid (substituted with Me, NO2, OH, OMe or Cl) preferably assisted by microwave irradiation Conversion of the amino group into a thiol preceded a base-induced intramol. substitution, also facilitated by microwave heating, to generate the second C-S bond of the target dibenzothiophene, e.g. I (R1 = MeO, R2 = R3 = R4 = H; R1 = R2 = R4 = H, R3 = Cl; R1 = R3 = R4 = H, R2 = OH). The 1-, 2-, 3- or 4-substituted 6-halodibenzothiophenes obtained were subjected to a palladium-mediated coupling with 2-morpholin-4-yl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-chromen-4-one to give the resp. 6-, 7-, 8- or 9-substituted dibenzothiophen-4-ylchromenones, e.g. II (R1 = MeO, R2 = R3 = R4 = H; R1 = R2 = R4 = H, R3 = Cl; R1 = R3 = R4 = H, R2 = OH). These compounds were evaluated as inhibitors of DNA-dependent protein kinase (DNA-PK) and compared to the parent 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholin-4-yl-4H-chromen-4-one. Notably, derivatives bearing hydroxy or methoxy substituents at C-8 or C-9 retained activity, whereas substitution at C-7 lowered activity. Substitution with chloro at C-6 was not detrimental to activity, but a chloro group at C-7 or C-8 reduced potency. The data indicate permissive elaboration of hydroxyl at C-8 or C-9, enabling the possibility of improved pharmaceutical properties, while retaining potency against DNA-PK. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Related Products of 38939-88-7

The Article related to dibenzothiophenylchromenone preparation structure activity relationship dna protein kinase inhibiting, suzuki coupling intramol substitution microwave irradiation dibenzothiophenylchromenone preparation and other aspects.Related Products of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 27, 2015, Stoll, Dwight R.; O’Neill, Kelly; Harmes, David C. published an article.Application of 99-60-5 The title of the article was Effects of pH mismatch between the two dimensions of reversed-phase × reversed-phase two-dimensional separations on second dimension separation quality for ionogenic compounds-I. Carboxylic acids. And the article contained the following:

Two persistent impediments to wider adoption of two-dimensional liquid chromatog. (2-dimensional-LC) are the perceptions that 2-dimensional methods are generally less sensitive than 1-dimensional ones, and that coupling of certain separation modes in a 2-dimensional system is difficult because of the neg. impact of the effluent of the 1st separation on the 2nd separation The authors address these problems in the specific case where reversed-phase separations were used in both dimensions of a 2-dimensional-LC system, but the pH is varied such that the ionization state of carboxylic acid analytes is different (i.e., neutral or neg. charged, in eluents buffered at pH 2 or 7) in the two columns. The authors 1st demonstrate that the effect of 1st dimension (1D) effluent on the performance of 2nd dimension (2D) separation of ionogenic solutes is much more serious than it is for neutral compounds where the pH of the eluent does not play a role in retention. The authors have systematically varied the properties of the sample solution injected into the 2D column (i.e., the 1D effluent), as well as the 2D eluent, with the goal of establishing guidelines for conditions that yield acceptable 2D performance. The organic solvent content of the 1D effluent and 2D eluent is not as important as the buffer concentrations in these two solutions, and the greater the ratio of buffer concentration in the 1D effluent relative to the 2D eluent, the smaller the volume one can inject into the 2D column before dramatic peak splitting occurs. The authors have then used the information from these simple experiments to guide both 1-dimensional experiments that mimic the 2D separation, and actual 2-dimensional separations, to demonstrate that online adjustment of the properties of the 1D effluent by dilution with a buffered solvent prior to injection into the 2D column is a very effective solution to the pH mismatch problem. When the buffer capacity of the diluent is high enough to effectively titrate the 1D effluent such that its pH approaches that of the 2D eluent, excellent 2D peak shape was obtained for the carboxylic acid analytes, even when the volume of injected sample solution exceeds the 2D column volume The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Application of 99-60-5

The Article related to ph mismatch 2d reversed phase liquid chromatog, carboxylic acid second dimension separation 2d lc, carboxylic acids, detection sensitivity, solvent mismatch, two-dimensional, volume overload, ph effects and other aspects.Application of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2020, Cieslikiewicz-Bouet, Monika; Naldi, Marina; Bartolini, Manuela; Perez, Belen; Servent, Denis; Jean, Ludovic; Araoz, Romulo; Renard, Pierre-Yves published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor. And the article contained the following:

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cholinergic dysfunction, provoking memory loss and cognitive dysfunction in elderly patients. The cholinergic hypothesis provided over the years with mol. targets for developing palliative treatments for AD, acting on the cholinergic system, namely, acetylcholinesterase and α7 nicotinic acetylcholine receptor (α7 nAChR). In our synthetic work, we used “click-chem.” to synthesize two Multi Target Directed Ligands (MTDLs) MB105 and MB118 carrying tacrine and quinuclidine scaffolds which are known for their anticholinesterase and α7 nAChR agonist activities, resp. Both, MB105 and MB118, inhibit human acetylcholinesterase and human butyrylcholinesterase in the nanomolar range. Electrophysiol. recordings on Xenopus laevis oocytes expressing human α7 nAChR showed that MB105 and MB118 acted as partial agonists of the referred nicotinic receptor, albeit, with different potencies despite their similar structure. The different substitution at C-3 on the 2,3-disubstituted quinuclidine scaffold may account for the significantly lower potency of MB118 compared to MB105. Electrophysiol. recordings also showed that the tacrine precursor MB320 behaved as a competitive antagonist of human α7 nAChR, in the micromolar range, while the quinuclidine synthetic precursor MB099 acted as a partial agonist. Taken all together, MB105 behaved as a partial agonist of α7 nAChR at concentrations where it completely inhibited human acetylcholinesterase activity paving the way for the design of novel MTDLs for palliative treatment of AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to preparation tacrine quinuclidine derivative ache nicotinic receptor, acetylcholinesterase, alpha 7 nicotinic acetylcholine receptor, alzheimer’s disease, butyrylcholinesterase, multi-target directed ligand and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Lei; Li, Kai; Xie, Chuandong; Li, Shan; Xu, Da; Qin, Wenling; Yan, Hailong published an article in 2019, the title of the article was Organocatalytic Asymmetric Annulation of ortho-Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-indoles.SDS of cas: 98946-18-0 And the article contains the following content:

A chiral Bronsted base catalyzed asym. annulation of ortho-alkynylanilines was developed to accessed axially chiral naphthyl-C2-indoles via vinylidene ortho-quinone methide intermediates. This strategy provided a unique organocatalytic atroposelective route to axially chiral aryl-C2-indole skeletons with excellent enantioselectivity and functional-group tolerance. This transformation was applicable to decagram-scale preparation (50.0g) with perfect enantioselectivity through simple recrystallization Moreover, the utility of this reaction was demonstrated by a variety of transformations towards chiral naphthyl-C2-indoles for a series of carbon-heteroatom bond formations. Furthermore, the prepared axially chiral naphthyl-C2-indoles were applied as a chiral skeleton for organocatalytic aza-Baylis-Hillman reaction and asym. formal [4+2] tandem cyclization to give the corresponding adducts in high yields with improved enantioselectivity and diastereoselectivity. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).SDS of cas: 98946-18-0

The Article related to anilinoethynyl naphthol cinchon alkaloid catalyst enantioselective heterocyclization, hydroxynaphthyl indole preparation, asymmetric catalysis, atroposelectivity, axially chirality, indoles, organocatalysis and other aspects.SDS of cas: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 15, 2021, Chai, Xin-Yue; Xu, Hui-Bei; Dong, Lin published an article.SDS of cas: 35444-44-1 The title of the article was Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C-H Activation. And the article contained the following:

An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biol. properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C-H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Addnl., a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to indole preparation, acyl indole bromoalkyne alkynylation carbonylation iridium catalyst, alkynylation, carbonylation, cascade reactions, iridium, multifunctional indole derivatives, multistep c−h activation and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics