Month: November 2022

Zhao, Jing; Jin, Yan; Shin, Yujin; Jeong, Kyung Min; Lee, Jeongmi published an article in 2016, the title of the article was Indirect enantioseparation of fluoxetine in mouse serum by derivatization with 1R-(-)-menthyl chloroformate followed by ultra high performance liquid chromatography and quadrupole time-of-flight mass spectrometry.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Here we describe a simple and sensitive anal. method for the enantioselective quantification of fluoxetine in mouse serum using ultra high performance liquid chromatog. with quadrupole time-of-flight mass spectrometry. The sample preparation method included a simple deproteinization with acetonitrile in 50 μL of serum, followed by derivatization of the extracts in 50 μL of 2 mM 1R-(-)-menthyl chloroformate at 45 C for 55 min. These conditions were statistically optimized through response surface methodol. using a central composite design. Under the optimized conditions, neither racemization nor kinetic resolution occurred. The derivatized diastereomers were readily resolved on a conventional sub-2 μm C18 column under a simple gradient elution of aqueous methanol containing 0.1% formic acid. The established method was validated and found to be linear, precise, and accurate over the concentration range of 5.0-1000.0 ng/mL for both R and S enantiomers (r2 > 0.993). Stability tests of the prepared samples at three different concentration levels showed that the R- and S-fluoxetine derivatives were relatively stable for 48 h. No significant matrix effects were observed Last, the developed method was successfully used for enantiomeric anal. of real serum samples collected at a number of time points from mice administered with racemic fluoxetine. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to fluoxetine determination enantioseparation serum menthyl chloroformate uplc qtof ms, chiral derivatization reagent, enantioseparation, fluoxetine, menthyl chloroformate, response surface methodology and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fujiwara, Shinichi; Cadou, Romain; Yamaoka, Yousuke; Takasu, Kiyosei; Yamada, Ken-ichi published an article in 2015, the title of the article was Hydrostannylation-cross-coupling strategy for the stereoselective synthesis of alkylidenemalonates and related α,β-unsaturated esters.SDS of cas: 14602-86-9 And the article contains the following content:

A method for the stereoselective synthesis of alkylidenemalonates and related α,β-unsaturated esters by hydrostannylation-cross coupling process was developed. Regio- and diastereoselective Pd-catalyzed hydrostannylation of propiolate derivatives provided α-alkoxycarbonyl (E)- and (Z)-vinylstannanes which were then converted into resp. alkylidenemalonates by the Stille coupling reaction with corresponding chloroformates. A one-pot process was also realizable for the Pd-catalyzed reactions. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to alkylidenemalonate alpha beta unsaturated ester preparation, vinyl stannane preparation chloroformate stille coupling, propiolate tributylstannane hydrostannylation regioselective diastereoselective and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 21, 2012, Yu, Juntian; Zhang, Ling; Sun, Zhiguo; Luan, Xiuli published a patent.Quality Control of 4-Chloro-2-fluorotoluene The title of the patent was Method for preparing 4-chloro-2-fluorotoluene. And the patent contained the following:

The invention relates to the method for preparation of 4-chloro-2-fluorotoluene. 4-Chloro-2-fluorotoluene was prepared via salt formation of 5-chloro-2-methylaniline with hydrofluoric acid; the resulting 5-chloro-2-methylaniline hydrofluoric acid salt underwent diazotization to give 5-chloro-2-methylphenyldiazonium fluoride, which underwent denitrogenation to give the title compound The method has few steps, high yield and high product purity. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene

The Article related to chloro methyl aniline salt formation, hydrofluoric acid salt chloro methyl aniline preparation diazotization, phenyl diazonium fluoride preparation denitrogenation, fluoro methyl toluene preparation and other aspects.Quality Control of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 1, 2019, Onder, Seda; Biberoglu, Kevser; Tacal, Ozden published an article.Computed Properties of 4569-86-2 The title of the article was The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. And the article contained the following:

Phenazines, naturally produced by bacteria and archaeal Methanosarcina species are nitrogen-containing tricyclic mols. with antibiotic, antitumoral, and antiparasitic activities. Phenazines are used as electron acceptors-donors in wide range of fields including environmental biosensors. In this study, the inhibitory effects of a synthetic phenazine dye, methylene violet 3RAX (also known as di-Et safranine) on human erythrocyte AChE and human plasma BChE were tested and also its inhibitory mechanisms for both enzymes were studied in detail. Kinetic anal. showed that methylene violet 3RAX acts as a hyperbolic noncompetitive inhibitor of AChE with Ki value of 1.58 ± 0.36μM; α = 1; β = 0.12 ± 0.0003. On the other hand, it caused linear competitive inhibition of BChE with Ki value of 0.51 ± 0.006μM; α = ∞. In conclusion, methylene violet 3RAX which is a highly effective inhibitor of both human AChE and human BChE with Ki values in low micromolar range may be a promising candidate for the treatment of Alzheimer’s disease. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Computed Properties of 4569-86-2

The Article related to human erythrocyte plasma acetylcholinesterase butyrylcholinesterase methylene violet inhibition kinetics, acetylcholinesterase, butyrylcholinesterase, cholinesterase inhibition, methylene violet 3rax and other aspects.Computed Properties of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2022, Ouyang, Yao; Xu, Xiu-Hua; Qing, Feng-Ling published an article.Recommanded Product: 80-07-9 The title of the article was Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen. And the article contained the following:

A conceptually new and operationally simple protocol for the direct C-H trifluoromethoxylation of (hetero)aromatics by the combination of the readily available trifluoromethylating reagent and oxygen under electrochem. reaction conditions was discussed. This reaction proceeded through the initial generation of CF3 radical followed by conversion to CF3O radical, addition to (hetero)aromatics and rearomatization. The utility of this electrochem. trifluoromethoxylation was illustrated by the direct incorporation of CF3O group into a variety of (hetero)aromatics as well as bio-relevant mols. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Recommanded Product: 80-07-9

The Article related to trifluoromethoxyarene preparation, arene trifluoromethyl pyridylsulfone electrochem trifluoromethoxylation, electrochemistry, oxygen, radical reactions, trifluoromethoxylation, trifluoromethyl groups and other aspects.Recommanded Product: 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2022, Ouyang, Yao; Xu, Xiu-Hua; Qing, Feng-Ling published an article.Product Details of 38939-88-7 The title of the article was Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen. And the article contained the following:

A conceptually new and operationally simple protocol for the direct C-H trifluoromethoxylation of (hetero)aromatics by the combination of the readily available trifluoromethylating reagent and oxygen under electrochem. reaction conditions was discussed. This reaction proceeded through the initial generation of CF3 radical followed by conversion to CF3O radical, addition to (hetero)aromatics and rearomatization. The utility of this electrochem. trifluoromethoxylation was illustrated by the direct incorporation of CF3O group into a variety of (hetero)aromatics as well as bio-relevant mols. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Product Details of 38939-88-7

The Article related to trifluoromethoxyarene preparation, arene trifluoromethyl pyridylsulfone electrochem trifluoromethoxylation, electrochemistry, oxygen, radical reactions, trifluoromethoxylation, trifluoromethyl groups and other aspects.Product Details of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Minghao; Hoover, Jessica M. published an article in 2016, the title of the article was Aerobic copper-catalyzed decarboxylative thiolation.HPLC of Formula: 99-60-5 And the article contains the following content:

Copper-catalyzed decarboxylative thiolation using mol. oxygen as the sole oxidant was developed. A variety of aromatic carboxylic acids including 2-nitrobenzoic acids, pentafluorobenzoic acid and several heteroaromatic carboxylic acids undergo efficient thiolation to furnish the aryl sulfides in moderate to excellent yields. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).HPLC of Formula: 99-60-5

The Article related to aryl sulfide selenide synthesis solvent effect, aromatic carboxylic acid decarboxylative thiolation selenation coupling copper catalyst, nitrobenzoic pentafluorobenzoic heteroaromatic carboxylic acid and other aspects.HPLC of Formula: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dowman, Luke J.; Agten, Stijn M.; Ripoll-Rozada, Jorge; Calisto, Barbara M.; Pereira, Pedro Jose Barbosa; Payne, Richard J. published an article in 2021, the title of the article was Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogs.Formula: C6H10Cl3NO And the article contains the following content:

Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogs and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogs for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallog. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Formula: C6H10Cl3NO

The Article related to peptide thrombin inhibitor synthesis sulfotyrosine, sulfonated aryl iodide negishi cross coupling iodoalanine, solid phase peptide synthesis microwave, thrombin crystal structure inhibitor mol docking and other aspects.Formula: C6H10Cl3NO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 1, 2020, Lemmerer, Andreas published an article.SDS of cas: 99-60-5 The title of the article was The 2-Chloro-4-nitrobenzoic acid as a coformer with pharmaceutical cocrystals and molecular salts. And the article contained the following:

A series of five binary complexes, i.e. three cocrystals and two mol. salts, using 2-chloro-4-nitrobenzoic acid as a coformer have been produced with five commonly available compounds, some of pharmaceutical relevance, namely, 2-chloro-4-nitrobenzoic acid-isonicotinamide (1/1), C7H4ClNO4·C6H6N2O, 2-chloro-4-nitrobenzoic acid-3,3-diethylpyridine-2,4(1H,3H)-dione (2/1), 2C7H4ClNO4·C9H13NO2, 2-chloro-4-nitrobenzoic acid-pyrrolidin-2-one (1/1), C7H4ClNO4·C4H7NO, 2-carboxypiperidinium 2-chloro-4-nitrobenzoate, C6H12NO2-·C7H3ClNO4-, and (2-hydroxyethyl)ammonium 2-chloro-4-nitrobenzoate, C2H8NO+·C7H3ClNO4-. The coformer falls under the classification of a generally regarded as safe compound All five complexes make use of a number of different heteromeric hydrogen-bonded interactions. Intermol. potentials were evaluated using the CSD-Materials module. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).SDS of cas: 99-60-5

The Article related to chloro nitrobenzoic acid coformer pharmaceutical cocrystal mol salt, uni force fields, chloronitrobenzoic acid, cocrystal, crystal structure, isonicotinamide, molecular salt, piperidinium, pyrrolidine and other aspects.SDS of cas: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 15, 2017, Fang, Zhen; Wang, Tian-qi; Li, Hui; Zhang, Guo; Wu, Xiao-ai; Yang, Li; Peng, Yu-lan; Zou, Jun; Li, Lin-li; Xiang, Rong; Yang, Sheng-yong published an article.Application of 99-60-5 The title of the article was Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors. And the article contained the following:

Herein the authors report the discovery of a series of new small mol. inhibitors of histone lysine demethylase 4D (KDM4D). Mol. docking was first performed to screen for new KDM4D inhibitors from various chem. databases. Two hit compounds were retrieved. Further structural optimization and structure-activity relation (SAR) anal. were carried out to the more selective one, compound 5-hydroxy-9-nitropyrazolo[1,5-a]quinazoline-3-carbonitrile, which led to the discovery of several new KDM4D inhibitors. Among them, compound 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile is the most potent one with an IC50 value of 0.41 ± 0.03 μM against KDM4D. Overall, compound 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile could be taken as a good lead compound for further studies. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Application of 99-60-5

The Article related to pyrazolopyrimidinecarbonitrile derivative preparation histone lysine demethylase 4d inhibitor, epigenetics, histone lysine demethylase, kdm4d, small molecule inhibitor, structure-activity relationship and other aspects.Application of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics